Senior Director, Commercial Forecasting

We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting‑edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T‑cell therapies and TCR bispecifics. Innovative Environment: Help to pioneer advancements in cancer immunotherapy. We are seeking a Senior Director, Commercial Forecasting & AI combined role. Approximately half of the position is owning demand, revenue and patient‑flow forecasting across Immatics’ portfolio — from early pipeline opportunity assessment through launch readiness and in‑line performance. The other half is serving as the Commercial organization’s in‑house AI expert: identifying, building and scaling AI and generative‑AI capabilities that make a small commercial team perform like a much larger one. The successful candidate is a recognized forecasting expert in oncology or cell and gene therapy who has already put AI to practical, compliant use in a life sciences commercial setting. Reports to: VP Commercial Analytics & Operations

Location:
Remote U.
Bachelor’s or equivalent years of experience 15+ years in Life sciences consultancy, biotech, pharma or related 7 Years of Forecasting, Commercial Analytics or market insights ~ Demonstrated expertise building patient‑based and epidemiology‑driven forecast models from the ground up for both pre‑launch and in‑line assets. ~ Deep working knowledge of pharma/biotech data sources and their strengths and limitations — e.g. IQVIA, Symphony Health, Komodo, Definitive Healthcare, specialty distributor and 867/852 data, SEER and other epidemiology sources, clinical registries and syndicated market research. ~ Demonstrated, hands‑on experience applying AI and large language models to real commercial problems in a regulated life sciences environment — including practical fluency with LLM platforms, prompt engineering, retrieval‑augmented generation and agentic workflows, and a clear‑eyed view of where AI does and does not work. ~ Working understanding of the compliance and privacy constraints on AI in life sciences (PHI/HIPAA, GDPR, promotional review, data licensing terms, emerging AI regulation). ~ Advanced Excel modeling plus working proficiency in Python, SQL and a visualization tool (Power BI/Tableau). ~ Direct experience forecasting an autologous CAR‑T, TCR‑T or other engineered cell therapy asset, including site activation and manufacturing‑constrained demand models. ~ Track record of standing up a forecasting or commercial AI capability at a pre‑commercial or newly commercial company. ~ Exposure to global forecasting and to market access/pricing analytics in specialty oncology. Develop Commercial AI roadmap — Serve as the Commercial team’s resident AI expert across the full commercial organization: partner with Marketing, Market Access, Medical Affairs and Field Operations to identify, prioritize and sequence high‑value AI and generative‑AI use cases — analytics and forecasting, market research synthesis, competitive intelligence, field enablement, content development and promotional review preparation, account and KOL intelligence, payer and policy monitoring, and CRM data quality — with a clear view of business impact, effort and sequencing. Build the operating systems — Design, build and own AI‑powered systems that become how Commercial runs day to day — not one‑off pilots. Re‑engineer the analytics workflow end to end so recurring work runs itself: automated ingestion and QC of claims, specialty distributor, CRM and third‑party data; and agentic workflows that take manual assembly off the critical path — shifting the team’s time from producing numbers to interpreting them. buy and vendors — Evaluate AI platforms and vendors, run structured pilots against defined success criteria, and make defensible build‑versus‑buy recommendations. Travel

Requirements:
10-15% Competitive rates for Health, Dental, and Vision Insurance ~4 weeks of vacation, granted up front each year and prorated for first and last year of employment. ~12 company paid holidays ~100% employer‑paid life insurance up to at 1x annual salary, up to one hundred thousand dollars ~100% employer‑paid short‑ and long‑Term disability coverage ~401(k) with immediate eligibility and company match. We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law. We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices or o