Application Scientist HPLC

3 weeks ago


Spring House PA, United States Insight Global Full time

Our large pharmaceutical clients is seeking a Scientist for Protein Biophysical Analysis to join their growing Binding Group in Spring House, PA. This team focuses on the development and application of preclinical assays in support of the discovery of therapeutic candidates. This individual will be responsible for the application of technologies for biophysical and biochemical characterization and is responsible for implementing methods for affinity analysis. The scientist works under minimal supervision exercising autonomy. Kinetics and affinity analysis of antigens and antibodies using SPR, BLI and KinExA.
Perform HPLC analyses to assess the hydrophobicity, size, and purity of proteins.
Characterization of molecules using mass spectrometry (MS).
Data analysis, Documentation, and reporting – ELNs, LIMS etc.,
Lab instrument maintenance – cleaning spray sources and calibration weekly, prepping calibration solutions.
Assist in drafting and executing peer reviewed posters, manuscripts, tech reports and patent filings.

Minimum of a Bachelor’s Degree in a related field of study
Experience in Biophysical Binding analysis methods (e.g., Solid understanding of protein biochemistry, binding affinity, thermodynamics, and antibody structure is preferred.
Pharmaceutical experience with mass spectrometry characterization of antibodies is preferred


Salary: $75,000-$90,000 (flexible based on experience)
Hours: Monday-Friday, 8:00am-5:00pm
Multiyear contract – After 1 year on contract, the individual will have the opportunity to apply for a permanent role or have their contract renewed for another year
PTO : 10 PTO days, 6 paid sick days annually & paid Holidays
Benefits: Medical, Dental, Vision and 401K plans available


Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching.



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