Principal Scientist, RPD

Aktis Oncology is a biotechnology company pioneering the discovery and development of a new class of targeted radiopharmaceuticals to treat a broad range of solid tumor cancers. Founded and incubated by MPM Capital with its seasoned team of entrepreneurs and drug developers, Aktis developed proprietary platforms to generate tumor targeting agents with ideal properties for radiotherapy. Designed for high tumor penetration and long residence time, Aktis Oncology's molecules can quickly clear other areas of the body, thereby maximizing tumor elimination while minimizing side effects of treatment. These are therapies that would also enable clinicians to visualize and verify target engagement prior to exposure to therapeutic radioisotopes. The experience expected from applicants, as well as additional skills and qualifications needed for this job are listed below. The Principal Scientist in the Radiopharmaceutical Development (RPD) team will be primarily responsible for the manufacturing and QC development of Aktis Oncology's proprietary radiopharmaceuticals in Aktis' R&D laboratory in Boston. The Principal Scientist will also contribute to Aktis Oncology's global radiopharmaceutical development and manufacturing program, including formulation development and stability testing, QC method development, and technology transfer to Aktis' Contract Manufacturing Organizations (CMOs). This individual will report to the Executive Director of Radiopharmaceutical Development and be an integral part of the CMC team contributing to the development of multiple portfolio programs. The position will collaborate closely with cross-functional team members to ensure timely delivery of robust manufacturing and QC protocols. Position title will be finalized commensurate with experience and accomplishments. This role requires full-time on-site presence. BACKGROUND AND QUALIFICATIONS 6+ years of experience with a PhD in chemistry, biology, engineering, or related field essential. 2+ years of experience in radiochemistry, including the use of radiometals, is essential. Experience with radiotherapeutics is highly preferred. Experience in the chemistry of proteins is preferred. Experience with analytical methods of radiopharmaceuticals, radio-HPLC, iTLC, HPGe, liquid scintillation and gamma counting essential. Project management and organizational skills, proven track record of setting priorities, and ability to work independently and as a team member. Strong desire to be part of a mission-oriented company leading transformative change for patients. A combination of private and public company experience is preferred. Proven demonstration of transparent communication and fostering open and diverse debate. Ability to work with agility and manage ambiguity. Personifies positive energy and exemplifies respect. ESSENTIAL DUTIES AND RESPONSIBILITIES Develop, optimize, and qualify radiolabelling and QC procedures for pre-clinical and early-phase clinical use. Aid in the development of laboratory operational protocols and participate in day-to-day laboratory operations, including radiation safety. Write development reports that can be used for the transfer of technology. xrczosw Coordinate with CMC project management efforts related to manufacturing and analytical method development, technology transfer, manufacture, release, and supply of drug substance/drug product Take on new challenges willingly and build a culture of rigor and data-driven decision making to bring novel therapies to the clinic Demonstrate high standards for scientific rigor, team behaviors, excellence and a culture of innovation that is fully aligned with company objectives Aktis Oncology is an Equal Opportunity Employer and does not discriminate on the basis of race, religion, color, sex, gender identity or expression, sexual orientation, age, disability, national origin, veteran status, or any other basis covered by appropriate law. Aktis Oncology is committed to promoting and maintaining a work environment in which all applicants, employees, and other individuals are treated with dignity and respect free from unlawful harassment, discrimination, or retaliation.