Senior Staff Engineer, Modeling

Senior Staff Engineer Process Modeling At Takeda, we are a forwardlooking, worldclass R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring lifechanging therapies to patients worldwide. Synthetic Molecule Process Development (SMPD) develops robust and costeffective processes for the manufacture of new smallmolecule pharmaceuticals, along with methods for achieving and controlling high standards of purity and quality. The Senior Staff Engineer Process Modeling will join a dynamic and innovative team of engineers and scientists within SMPDs Process Engineering & Technology Group. As a Senior Staff Engineer Modeling you will leverage a strong background in chemical reaction engineering to tackle and lead challenging problems in chemical reactions. You will develop and scale up models for unit operations using both firstprinciple and databased approaches, apply process analytical technologies (PAT) combined with statistical and firstprinciple models, and drive insilico process design, development, and optimization. You will report to the Associate Engineering Fellow. How You Will Contribute Lead and contribute to the design, development, optimization, and scaleup of manufacturing processes for synthetic molecule drug substances using process modeling and simulation principles. Utilize advanced process modeling tools and digital twin functionalities, implementing modelbased design of experiments for process characterization and risk assessment. Lead and develop experimental designs and workflows for model development, validation, and verification. Collaborate with crossfunctional and external partners to develop and deploy digital twins of unit operations. Partner with Automation, Manufacturing, Process Engineers, and PAT experts to develop modeling and simulation (M&S) solutions that can be deployed across the global organization for insilico process design, development, and optimization. Recommend, justify and implement insilico tools and an insilico first approach to process development. Contribute to the democratization of modeling and simulation tools & results within global SMPD. Develop project or significant technical strategy and leverage technical skill(s) as a resource/expert within the department. Recognized as a technical expert and resource within the function. Contribute significantly and independently to project work as well as the development of platforms, which may include multiple projects within the functional area. Proactively analyze technical issues and coordinate potential resolutions with project team members based on model and simulation predictions. Review, interpret and communicate data crossfunctionally within pharmaceutical sciences and project teams. Assume significant technical responsibility for a project area/technical program within the department and potentially across pharmaceutical sciences. Stay current in novel process modeling and simulation tools and platforms, identify process trends and champion process strategy. Influence and support initiatives related to driving scientific and technical improvement within the function and potentially crossfunctionally. Identify topics for initiatives and lead local/global initiatives on behalf of senior staff. Author relevant sections of regulatory documents, validation plans, reports and peerreviewed manuscripts. Identify vendors and build relationships to gain access to technologies as needed to deliver on pipeline and platform technology goals. Manage key vendor relationships across multiple projects as appropriate, and proactively affect resolution of issues arising at vendors. Represent Takeda and be an active member on precompetitive collaborations with academic and industrial partners. Required Minimum Requirements/Qualifications Bachelors degree in Chemical Engineering or a related pharmaceutical science with 11+ years of relevant industry experience. Masters degree in Chemical Engineering or a related pharmaceutical science with 9+ years of relevant industry experience. Ph.D. or postdoctoral fellowship in Chemical Engineering or a related pharmaceutical science with 3+ years of relevant industry experience. Strong knowledge and understanding of chemical reaction engineering and catalysis, with proven ability to demonstrate skills in these fields. Strong knowledge and understanding of transport phenomena and thermodynamics. Extended experience with commercially available reaction kinetic modeling software such as Ansys, ReactionLab, Dynochem, and gPROMS. Extended experience with commercially available software for computational fluid dynamics (CFD) modeling such as Ansys, Star CCM+, MStar CFD. Proficient in communicating and data collection from systems such as sensors, controllers, and industrial systems. Experience with Matlab, Python, R, SQL, and good coding practices. Preferred Qualifications Experience with common statistical methods, basic data science principles, and AI/ML methodologies. Handson experience in wet lab process development. Experience in multivariate analysis and Principal Component Analysis (PCA). Understanding of synthetic molecule process development activities. Understanding of current Good Manufacturing Practices (cGMP). Knowledge and Skills Analytical and problemsolving skills able to troubleshoot critical issues or problems, and determine causes and possible solutions. Teamwork ability to work well in highly crossfunctional team environments and across global line functions. Communication skills able to express oneself clearly and concisely within the team; document issues and concerns concisely with colleagues; adjust communication style as appropriate for the audience; timely and effectively communicate issues to supervisor; technical writing skills to support authorship of internal technical documents. Organization exercises good timemanagement and prioritization skills and can manage multiple tasks simultaneously. Knowledge sharing ability to capture organizational knowledge; improve solutions, processes, and deliverables through use of information; improve information capital by contributing experience, theories, deliverables, and models for others to use. Resource management ability to manage time within individual, departmental, and corporate goals and timelines; management of internal and external resources (vendors). External involvement demonstrated involvement in professional community evidenced by presentation of scientific posters or lectures at professional conferences or events. Technical subjectmatter expertise and knowledge of applicable process modeling and simulation tools. Travel Requirements May require approximately 510% travel. More About Us At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and bestinclass patient support programs. Takeda is a patientfocused company that will inspire and empower you to grow through lifechanging work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver better health and a brighter future to people around the world. Takeda Compensation And Benefits Summary Location: Boston, MA U.S. Base Salary Range: $137,000.00 $215,270.00 U.S. based employees may be eligible for shortterm and/or longterm incentives. Employees may participate in medical, dental, vision insurance, a 401(k) plan with company match, shortterm and longterm disability coverage, basic life insurance, tuition reimbursement, paid volunteer time off, company holidays, and wellbeing benefits. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Job Details Location: Boston, MA Worker Type: Employee Worker SubType: Regular Time Type: Full time Job Exempt: Yes Seniority Level: MidSenior level Employment Type: Fulltime Job Function: Engineering and Information Technology Industries: Internet News #J-18808-Ljbffr