Senior Scientist of Bioanalysis
2 weeks ago
Mantell Associates is currently partnered with an exciting Life Science organisation in their search for a Senior Scientist of Bioanalysis to join their growing team.
Senior Scientist of Bioanalysis - Responsibilities:
- Develop, validate, and implement bioanalytical assays for the characterization of antibody drug candidates across various therapeutic areas.
- Perform chromatography-based analyses including HPLC, UPLC, LC-MS, SEC, HILIC, and electrophoresis techniques to evaluate the properties and stability of antibody molecules.
- Design and conduct experiments to assess post-translational modifications and sources of heterogeneity in monoclonal antibodies (e.g., charge variants, N-glycans, peptide mapping).
- Use a variety of biophysical techniques (e.g., CD, fluorescence, DSC) to assess the stability, folding, and functional properties of complex antibody molecules.
- Ensure compliance with regulatory guidelines and industry standards in the design and execution of bioanalytical assays and drug development processes.
- Collaborate with internal teams to support drug development by providing analytical data that informs decision-making and ensures the success of preclinical and clinical stages.
- Prepare and review technical reports, presentations, and regulatory submissions, ensuring clear communication of analytical results to both internal teams and external stakeholders.
- Mentor and guide junior scientists, providing leadership and fostering a collaborative environment to achieve project goals and maintain high standards of analytical performance.
Senior Scientist of Bioanalysis - Requirements:
- Ph.D. in Analytical or Bio-Analytical Chemistry with at least 2 years of industrial experience, OR a Master's degree with 5+ years of industrial experience, OR a Bachelor's degree with 8+ years of industrial experience.
- Strong hands-on experience in developing, validating, and implementing chromatography assays, particularly for antibody-based therapeutics.
- In-depth knowledge and practical expertise in at least five bioanalytical technologies, including chromatography (HPLC, UPLC, LC-MS), electrophoresis (CGE, iCE), SDS-PAGE, immunochemical assays (ELISA, Western blot), and protein characterization techniques.
- Demonstrated experience with biophysical characterization techniques for assessing antibody stability and structure (e.g., CD, fluorescence, DSC).
- Knowledge of the regulatory landscape for bioanalytical development, including GMP and GLP requirements for biopharmaceuticals.
- Proven ability to work collaboratively in a fast-paced, multidisciplinary team environment, with excellent problem-solving, communication, and organizational skills.
Mantell Associates is a specialist Pharmaceutical and Life Sciences headhunting firm. For more information on this role, please contact us at +44 (0)20 3854 7700.
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