Research Scientist

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Vertex Pharmaceuticals. and R&D operations based in Boston, Massachusetts and San Francisco, California.
We are seeking a highly motivated Senior Scientist/Principal Scientist to join our Analytical Development team focused on LNP delivered in vivo therapeutics. This individual will be a key contributor to method development for LNP and related modalities, working both hands-on in the lab and in collaboration with contract labs (CROs). The successful candidate will bring a deep understanding of analytical methods, regulatory requirements, and a passion for innovation and problem-solving in a fast-paced environment.
Hands-on development, execution and troubleshooting of analytical assays to characterize and quantify LNPs and related materials.
Serve as a technical lead and subject matter expert (SME) for analytical projects at CMOs/CROs ensuring scientific rigor and regulatory compliance.
Provide analytical expertise for comparability studies to support manufacturing process changes and product lifecycle management.
Author and review SOPs, analytical protocols, technical reports, and regulatory submission documents (e.g., Interpret and present complex analytical data with clarity to internal stakeholders and regulatory agencies.
Mentor and/or supervise junior scientists, providing guidance on experimental design, troubleshooting, and career development.
Collaborate cross-functionally with Research, Process Development, Quality, and Regulatory teams to support program advancement from early development and preclinical through clinical and commercial stages.
PhD in Biochemistry, Molecular Biology, Analytical Chemistry, or related discipline with
Senior Scientist: 5+ years of relevant industry experience, or non-PhD and 12+ years progressive, relevant experience.

Strong understanding of in vivo gene therapy delivery platforms.
Advanced analytical and data analysis skills.
Experience working with external laboratories (CMOs/CROs) for method development and stage-appropriate validations.
Understanding of regulatory and compendial expectations (e.g., Scientific curiosity and creativity.
Prior experience with analytical support for regulatory filings (e.g., Familiarity with platform analytical approaches for mRNA therapeutics and LNP-formulated Cell and Gene Therapy products.
Experience with liquid handler platforms and method automation.
Passion for science, high level of integrity, and a proactive mindset aligned with core values of collaboration, undaunted spirit, resilience, and entrepreneurship.
Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.


Senior Scientist: Base pay range of $147,000 to $160,000 + bonus, equity and benefits
Principal Scientist: Base pay range of $171,000 to $185,000 + bonus, equity and benefits
xrczosw The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.