Post Doctoral Fellow

3 weeks ago

Columbia SC United States University of South Carolina Full time
Logo For Posting:

Posting Number:

RTF00247PO24

USC Market Title:

Post Doctoral Fellow

Link to USC Market Title:

Business Title (Internal Title):

Post Doctoral Fellow

Campus:

Columbia

Work County:

Richland

College/Division:

College of Arts and Sciences

Department:

CAS Chemistry and Biochemistry

Advertised Salary Range:

$61,008

Part/Full Time:

Full Time

Hours per Week:

37.5

Work Schedule:

Monday - Friday, 8:30am - 5:00pm

Must be willing to work a flexible schedule to meet the needs of the department.

Type of Staff Position:

Staff Research Grant (SRGP)

Basis :

12 months

Job Search Category:

Post-doctoral

About University of South Carolina:

From the Upstate to the Lowcountry, the University of South Carolina system is transforming the lives of South Carolinians through the impact of our eight institutions and 20 locations throughout the state. More than 50,000 students are enrolled at one of eight institutions, including the research campus in Columbia and comprehensive four-year universities in Aiken, Upstate and Beaufort. In addition, our Palmetto College campuses in Salkehatchie, Union, Lancaster and Sumter enable students to earn associate or bachelor's degrees through a combination of in-person, online or blended learning. All of our system institutions place strong emphasis on service - helping to build healthier, more educated communities in South Carolina and beyond.

Inclusive Excellence Statement:

At the University of South Carolina, we strive to cultivate an inclusive environment that is open, welcoming, and supportive of individuals of all backgrounds. We recognize diversity in our workforce is essential to providing academic excellence and critical to our sustainability. The University is committed to eliminating barriers created by institutional discrimination through accountability and continuous process improvement. We celebrate the diverse voices, perspectives, and experiences of our employees.

South Carolina Retirement:

Yes

State Insurance Programs:

Yes

Annual Leave:

Yes

Sick Leave:

Yes

Advertised Job Summary:

The postdoctoral fellow will be responsible for analyzing biosynthetic genes, identifying and isolating natural products, determining the chemical structures of the natural products and elucidating the corresponding biosynthetic pathways. The postdoctoral fellow will also be responsible for data analysis, preparation of written reports and manuscripts, as well as mentoring graduate students in the laboratory.

Required Education and Experience:

Requires a Doctoral (Ph.D.) degree in area of specialty.

Preferred Qualifications:

The candidate should have a Ph.D. degree in chemistry, biochemistry or related field by the start date of employment with expertise in natural products chemistry, genome mining, or biosynthesis. This expertise could have been gained during the normal course of a doctoral degree program.

Knowledge/Skills/Abilities:

Natural products chemistry is required; natural products metabolomics, biosynthesis and biological evaluation would be a plus.

Job Duty:

Performs microbial genome mining, biosynthetic gene cluster cloning/capture and expression. Exploring microbial genomes to find genes or biosynthetic gene clusters (BGCs) that have a particular function, often related to the biosynthesis of natural products like antibiotics or other metabolites, using bioinformatic tools. After identification, the candidate will clone these genes or BGCs, typically using techniques like PCR amplification, TAR cloning, and vector-based transformation or conjugation, into more manageable host organisms, such as E. coli or Streptomyces to produce target compounds. The expression condition will be optimized as necessary to efficiently harness the novel compounds they produce, paving the way for potential applications in medicine.

Essential Function:

Yes

Percentage of Time:

25

Job Duty:

Performs compounds isolation and structure elucidation.Isolating the novel natural products produced by the BGCs using a combination of various chromatography systems such as LH-20, C18 silica gel, and HPLC. Upon isolation of the compounds, the candidate will use NMR, UV, IR, HRMS, and x-ray diffraction to elucidate the chemical structures of these compounds.

Essential Function:

Yes

Percentage of Time:

25

Job Duty:

Performs biosynthetic pathway and enzymology study. Investigating biosynthetic pathways - sequences of enzymatic reactions that lead to the synthesis of complex molecules from simpler precursors. The candidate will express and purify enzymes involved in the biosynthetic pathway, identify intermediates, determine the kinetic parameters of enzymes, further illuminate the enzyme's specificity and mechanism.

Essential Function:

Yes

Percentage of Time:

25

Job Duty:

Assists with biological/physiological study of the compounds discovered. Facilitating a multifaceted exploration into the interactions, impacts, and implications of novel compounds. The candidate will conduct the in vitro assessment of the compounds, often utilizing cell lines to ascertain biological activities, such as potential cytotoxicity, cell proliferation, or specific biomarker modulation. Colonization of mice with certain microbe may also be performed, followed by analysis of a variety of biomarkers and/or phenotypes.

Essential Function:

Yes

Percentage of Time:

10

Job Duty:

Work with the PI to write manuscripts and reports on funded projects.The candidate will lead the writing of journal articles and intellectual property disclosures emerging from research activities. It is expected that the successful candidate will be experienced in the preparation of publication-quality research artwork and narrative descriptions of results and background. The candidate will work with and receive feedback from the PI to continue to develop their expertise in the field.

Essential Function:

Yes

Percentage of Time:

10

Job Duty:

Assists in supervising graduate and undergraduate students in their research projects. The candidate will work with the PI to mentor graduate and undergraduate students in maintaining a productive laboratory environment

Essential Function:

Yes

Percentage of Time:

5

Hazardous weather category:

Non-Essential

Employees in Safety-Sensitive or Security-Sensitive positions will be subject to pre-employment and post-employment drug testing in accordance with University policy HR 1.95 Drug and Alcohol Testing.:

No

Number of Vacancies:

1

Desired Start Date:

10/16/2024

Position End Date :

10/15/2025

Job Open Date:

08/27/2024

Job Close Date:

11/25/2024

Open Until Filled:

No

Special Instructions to Applicant:

Positions are advertised for a minimum of five (5) business days on our job website. After five (5) business days, positions can be closed at the discretion of the department at any time. This employment site is updated on a regular basis. The length of the recruitment and screening process may vary from position to position, depending upon a variety of factors. Should review of your qualifications result in a decision to pursue your candidacy, you will be contacted by phone or email.



We are only accepting applications submitted by November 25, 2027.

Quicklink for Posting:

EEO Statement:

The University of South Carolina does not discriminate in educational or employment opportunities or decisions for qualified persons on the basis of age, ancestry, citizenship status, color, disability, ethnicity, familial status, gender (including transgender), gender identity or expression, genetic information, HIV/AIDs status, military status, national origin, pregnancy (false pregnancy, termination of pregnancy, childbirth, recovery therefrom or related medical conditions, breastfeeding), race, religion (including religious dress and grooming practices), sex, sexual orientation, veteran status, or any other bases under federal, state, local law, or regulations.

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