Senior Director, Medicinal Chemistry
3 weeks ago
OverviewMonte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company pioneering the discovery and development of molecular glue degraders (MGDs) to eliminate disease-causing proteins previously considered undruggable. We are seeking an accomplished and collaborative Senior Director of Medicinal Chemistry to lead and shape our drug discovery efforts in Boston. This leadership role will be central to advancing our growing pipeline from hit identification through development candidate nomination and IND-enabling studies. The ideal candidate will bring deep medicinal chemistry expertise, strong leadership capabilities, and a passion for driving innovative science toward transformative medicines.ResponsibilitiesLead Monte Rosa’s Boston Medicinal Chemistry group with scientific rigor, creativity and urgency, to deliver novel protein degraders into clinical development.Design and execute medicinal chemistry strategies from early discovery through candidate selection, applying structure- and property-based design.Drive compound design and optimization, integrating SAR, ADME/DMPK, pharmacology, and safety data to achieve optimal target product profiles.Collaborate with computational chemistry to apply machine learning and AI tools for molecular design and optimization.Work as a team and in close partnership with Basel Medicinal Chemistry and global Discovery Chemistry groups.Inspire and develop a team of experienced medicinal chemists, fostering innovation, collaboration, and cross-site synergy.Partner cross-functionally with biology, biophysics, DMPK, and computational teams to enable data-driven decisions and accelerate discovery timelines.Direct and manage external CRO partnerships, ensuring efficient execution of complex synthetic routes and timely compound delivery.Represent Monte Rosa’s science and strategy at internal governance meetings and external scientific forums, with clarity and impact.Mentor and develop next-generation scientific leaders within the medicinal chemistry organization.QualificationsPhD in Organic or Medicinal Chemistry with 15+ years of post-graduate experience in small molecule drug discovery within biotech or pharma.Proven track record of leadership in advancing programs from hit-to-lead through candidate nomination and IND-enabling studies.Knowledge and ideally experience proximity inducing modalitiesDemonstrated excellence in modern medicinal chemistry, including property-based optimization, hypothesis-driven design, and integration of structure-based and computational approaches.Deep understanding of DMPK, pharmacology, and safety optimization principles.Strong synthetic chemistry foundation with creativity in solving complex chemical challenges.Experience of managing cross-functional and cross-site teams, including external research collaborations and CRO networks.Exceptional communication and influencing skills, capable of articulating scientific vision and strategy across levels and disciplines.Track record of building strong teamsStrategic thinker with the ability to balance hands-on problem solving and high-level scientific direction. #J-18808-Ljbffr
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Senior Director, Medicinal Chemistry
3 weeks ago
Boston, United States Monte Rosa Therapeutics Full timeOverview Monte Rosa Therapeutics (MRT) is a clinical‑stage biotechnology company pioneering the discovery and development of molecular glue degraders (MGDs) to eliminate disease‑causing proteins previously considered undruggable. We are seeking an accomplished and collaborative Senior Director of Medicinal Chemistry to lead and shape our drug discovery...
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Senior Director, Medicinal Chemistry
3 days ago
Boston, United States Takeda Full timeDescription We are seeking a seasoned and visionary Senior Director of Medicinal Chemistry to join our leadership team. This individual will play a pivotal role in shaping the future direction of our company by providing strategic guidance and oversight to our medicinal chemistry efforts. The ideal candidate will be instrumental in driving our drug discovery...
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Senior Director, Medicinal Chemistry
4 days ago
Boston, MA, United States Takeda Full timeSenior Director, Medicinal Chemistry at Takeda Base pay range: $208,200.00/yr - $327,140.00/yr Job Description We are seeking a seasoned and visionary Senior Director of Medicinal Chemistry to join our leadership team. This individual will play a pivotal role in shaping the future direction of our company by providing strategic guidance and oversight to our...
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Director, Medicinal Chemistry
3 weeks ago
Boston, United States HotSpot Therapeutics, Inc Full timeFull-time, hybrid role based in Boston, MA At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines. Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called regulatory hotspots – that can be exploited through small molecule drug discovery. Regulatory...
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Director, Medicinal Chemistry
2 weeks ago
Boston, United States HotSpot Therapeutics, Inc Full timeFull-time, hybrid role based in Boston, MAApply (by clicking the relevant button) after checking through all the related job information below.At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines. Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called...
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Senior Director, Medicinal Chemistry
3 weeks ago
Boston, MA, United States Monte Rosa Therapeutics Full timeOverview Monte Rosa Therapeutics (MRT) is a clinicalstage biotechnology company pioneering the discovery and development of molecular glue degraders (MGDs) to eliminate diseasecausing proteins previously considered undruggable. We are seeking an accomplished and collaborative Senior Director of Medicinal Chemistry to lead and shape our drug discovery efforts...
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Boston, United States Monte Rosa Therapeutics, Inc Full timeA biotechnology company in Boston is seeking a Senior Director of Medicinal Chemistry to lead drug discovery efforts. The ideal candidate will have a PhD in Organic or Medicinal Chemistry and over 15 years of experience in biotech. Responsibilities include leading the chemistry group, managing drug discovery strategies, and collaborating with...
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Senior Director, Medicinal Chemistry
3 weeks ago
Boston, MA, United States Monte Rosa Therapeutics, Inc Full timeOverview Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company pioneering the discovery and development of molecular glue degraders (MGDs) to eliminate disease-causing proteins previously considered undruggable. We are seeking an accomplished and collaborative Senior Director of Medicinal Chemistry to lead and shape our drug discovery...
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Director, Medicinal Chemistry
4 weeks ago
Boston, MA, United States HotSpot Therapeutics, Inc Full timeFull-time, hybrid role based in Boston, MA Apply (by clicking the relevant button) after checking through all the related job information below. At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines. Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins –...
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Director, Medicinal Chemistry
1 week ago
Boston, MA, United States HotSpot Therapeutics, Inc Full timeFull-time, hybrid role based in Boston, MA Read the overview of this opportunity to understand what skills, including and relevant soft skills and software package proficiencies, are required. At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines. Through a proprietary technology platform, we are uncovering privileged allosteric...
