Associate Director, Functional Genomics, GETC

About Arc InstituteArc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.Arc aims to fund, develop, and support scientific work with a culture focused on scientific curiosity, truth, collaboration, and ambitious long-term goals across neurodegeneration, cancer, and immune dysfunction.Arc has scaled to over 300 people to date with $650M+ in committed funding and a state-of-the-art new lab facility in Palo Alto.About the positionWe are looking for an Associate Director to join our Genome Engineering Technology Center and lead the development and application of cutting-edge functional genomics approaches focused on high-throughput interrogation of mammalian genomes, transcriptomes and epigenomes with rich multi-omic readouts. This work supports Arc’s Virtual Cell Initiative, aiming to build an AI model that predicts how a cell behaves based on its initial characteristics and genetic changes. Success would improve target identification for drug discovery and advance diagnosis, treatment, and prevention of diseases.You will work closely with scientists and research associates in Arc’s Technology Centers and Core Investigator labs to develop technology for understanding and treating complex genetic disease. The ideal candidate will have a passion for technology development and a proven track record in high-throughput CRISPR screens in mammalian cells.This is an excellent opportunity for a motivated scientist and team leader at the intersection of basic research and biotech product development. Title and compensation will be competitive with industry jobs relative to experience and background.About YouYou are a leader and an expert in functional genomics – specifically in the domain of application of pooled screening approaches across cell types.You are innovative and think deeply about leveraging cutting-edge functional genomics tools to understand human health.You are a collaborator and enjoy working with scientists from other teams, labs, and scientific domains.You are a problem solver who can tackle ambitious, large-scale projects while maintaining high data quality.You are curious and eager to learn new biology, onboard new technologies, and deepen your understanding of machine learning.In this position, you willManage your functional genomics team through mentoring and training a team of scientists and research associates.Execute large-scale single-cell perturbation projects across diverse cellular contexts in vitro to develop a best-in-class generalized ML model, in collaboration with other Arc technology teams.Serve as a domain expert in functional genomics and pooled screens across the organization via a highly collaborative approach.Contribute biomedical domain knowledge to applications of virtual cell models for target identification in complex human disease, including Alzheimer’s disease.Execute project management, data management, and team coordination to drive internal clarity and progress.Present data in internal and external meetings and through publications.Job RequirementsPhD in molecular biology, bioengineering, genomics, cell biology, or similar fields8+ years of post-PhD experience in academia or the biotechnology industry3+ years of previous managerial experience leading and growing scientific teams of 3+Demonstrated ability to execute functional genomics screens with strong data qualityDeep understanding of CRISPR editing systems and their application to pooled screensExperience with cell culture and engineering of diverse mammalian cell typesAbility to develop optimal editing reagents, delivery vectors and custom guide RNA libraries for high-throughput pooled screensAbility and desire to work in a fast-paced environment and be a team playerInterest in close collaboration with our bioinformatics and machine learning teams to co-develop screen designsPreferred QualificationsPrior experience in complex human disease biology to enable longer-term contributions to therapeutic evaluation and application of our virtual cell model is a plus.CompensationThe base salary range for this position is $160,000 to $207,500. These amounts reflect the range of base salary that Arc reasonably would pay a new hire or internal candidate for this position. The actual base compensation paid to any individual may vary depending on factors such as experience, market conditions, education/training, skill level, and internal equity. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors. #J-18808-Ljbffr