Senior Scientist, Peptide Chemistry

Position Summary

We are seeking a highly skilled and motivated Senior Scientist specializing in Peptide Chemistry to join our dynamic research and development team. The ideal candidate will play a key role in the design, synthesis, and characterization of novel peptide-based therapeutics, contributing to the advancement of our drug discovery pipeline. This position offers an exciting opportunity to lead and collaborate within a multidisciplinary team, driving innovation and scientific excellence in the field of peptide chemistry. This position reports to the VP, Drug Discovery.

Key Responsibilities

* Lead the design and execution of complex synthetic routes for the development of novel peptide-based compounds, ensuring high-quality and efficient synthesis processes.
* Utilize advanced analytical techniques, such as HPLC, MS, NMR, and other spectroscopic methods, to characterize and validate the chemical properties of synthesized peptides.
* Conduct thorough literature reviews and stay abreast of the latest developments in peptide chemistry and related fields, integrating new knowledge and methodologies into research projects.
* Collaborate with cross-functional teams to develop and optimize peptide-based drug candidates, contributing to the evaluation of structure-activity relationships and pharmacokinetic properties.
* Actively participate in the planning and implementation of research strategies, including the design of experimental protocols, data analysis, and interpretation to support the achievement of project milestones.
* Mentor and provide guidance to other scientists, fostering a collaborative and intellectually stimulating environment for scientific growth and development.
* Contribute to the drafting of research reports, publications, and patent applications, effectively communicating scientific findings and discoveries to internal stakeholders and the broader scientific community. · Maintain a strong commitment to laboratory safety, adhering to established protocols and practices, and ensuring compliance with regulatory guidelines and industry standards

Education

* Ph.D. in Organic Chemistry, Chemical Biology, or a related discipline with a focus on peptide chemistry.

Experience

* A minimum of 5-7 years of relevant industry experience in peptide synthesis, purification, and characterization, preferably within a biotechnology or pharmaceutical research environment.
* Proven expertise in the design and execution of complex synthetic strategies, as well as in-depth knowledge of modern peptide chemistry techniques and methodologies.
* Strong proficiency in utilizing analytical instruments, such as HPLC, MS, NMR, and other spectroscopic tools, for the characterization and analysis of peptide compounds.
* Demonstrated ability to work effectively in a collaborative team environment, with excellent communication skills and a track record of successful interdisciplinary collaboration.
* A strong publication record in reputable scientific journals and/or demonstrated ability to contribute to intellectual property development through patent applications or related activities.

Additional Skills and Qualifications

* Some travel expected in pursuit of company objectives and presence at scientific conferences.

Company Overview:

MBX Biosciences is a clinical-stage biopharmaceutical company pioneering Precision Endocrine Peptide (PEP) therapeutic candidates to help people with endocrine disorders live fuller and healthier lives.

A distinguishing strength of MBX is world-class proprietary peptide drug discovery. Our team is driven to transform the current treatment landscape with highly efficacious, safe, and convenient medicines that are designed to address unmet needs in both rare and prevalent endocrine diseases. We are combining our deep expertise in peptide discovery and development with our novel, proprietary platform technology to advance our pipeline.

Our lead programs have clinically validated targets and attractive endocrine disease market opportunities. MBX 2109 is an investigational long-acting parathyroid hormone peptide prodrug in development as a PTH replacement therapy for the treatment of hypoparathyroidism. The company is building a pipeline of additional product candidates to treat endocrine disorders that will enter Phase 1 development in 2023.

MBX is supported by leading life science investors including Frazier Life Sciences, New Enterprise Associates, OrbiMed, Wellington Management, RA Capital and Norwest Venture Partners. We are based in the Indianapolis area and growing rapidly in a hybrid workplace environment. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, passionate about their work, and able to work in a dynamic environment.

EEO Statement:

MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.