Vice President, Clinical Science

3 weeks ago

Redwood City, United States Third Rock Ventures Full time

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Reporting directly to Chief Medical Officer, the VP Clinical Development will provide leadership, clinical development strategy, and oversight of clinical science deliverables for Revolution Medicines' clinical programs. Additionally, the Vice President of Clinical Science will provide supervision and management to Medical Directors and Clinical Scientists.

The Vice President of Clinical Science will have the following specific responsibilities:

* Responsible for the delivery of clinical strategy for the pipeline.


* Standing member of the program governance body.


* Responsible for protocols and investigator brochures for clinical stage molecules.


* Develop/manage infrastructure, processes, budget, etc. for the Clinical Development Organization.


* Hire, develop, and oversee the work of direct/indirect reports within the Clinical Development Organization.


* Drive protocol development by leading and partnering with a cross-functional team, including Research, Biometrics, Clinical Operations, Development Diagnostics, and Regulatory.


* Represent clinical with external stakeholders including investigators, key opinion leaders, and investors.


* Play a leadership role in the design and timely and high-quality implementation of Phase 1-4 clinical studies.


* Play a leadership in global regulatory submission and registration.


* Partner with cross-functional groups to map out clinical and regulatory strategies.


* Collaborate with clinical operations on investigator selection and engagement.


* Partner with the Research and Development Diagnostics groups to assure alignment of diagnostics strategy including patient selection and development of companion diagnostics.


* Oversee the review, analysis, and reporting of clinical data in collaboration with biometrics to enable internal decision making and regulatory filings.


* Lead the preparation and execution for clinical presentations at scientific conferences.



Required Experience, Skills, and Education:

* M.D. (or non-US equivalent) or MD/PhD, board certified.


* Training in medical oncology preferred.


* A minimum of 10-15 years of experience in the pharmaceutical/biotech industry or academia, preferably the majority in oncology drug development.


* A minimum of 5-10 years of leadership and management experience.


* Extensive experience in protocol design, implementation, and management of global phase 1-4 clinical trials.


* Direct experience interfacing with regulatory agencies, strong working knowledge and understanding of regulatory requirements for drug development, and preferably approval in more than one key region (ie. US, EU, Japan).


* Outstanding knowledge of industry issues and competitive landscape in oncology.


* Anticipates future trends and has a broad perspective of competitive landscape and regulatory implications on clinical development; ability to effectively communicate visions of possibilities and probabilities to executive management as well as cross-functional teams.


* Excellent track record and reputation in the industry, well-networked influencer and engager who regularly leverages such relationships to extend research, development and business opportunities.


* Experience networking with key opinion leaders in oncology and more specifically RAS and mTOR signaling pathways highly preferred.


* Outstanding leadership, collaboration, and teamwork in cross-functional setting; comfortable with a hands-on leadership position.


* Effective prioritization and decision making.


* Consistently drive for results by setting aggressive but achievable goals.


* Inspires and motivates others to the highest levels of performance and quality within the Clinical Science Organization and beyond.


* Excellent verbal and written communication skills and collaborative interpersonal skills.


* Travel required.



The expected salary range for this role is $265,000 to $350,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

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