Scientist, Metabolism
2 weeks ago
Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
As a Scientist on our team, you will:
* Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
* Develop assays to measure hepatocyte function both ex vivo and in vivo
* Evaluate epigenetic reprogramming payloads using ex vivo and in vivo functional assays to select therapeutic candidates
* Develop methods for in vivo delivery of nucleic acid payloads to hepatocytes in collaboration with our Epigenetic Editing team
* Analyze and interpret experimental data to drive pre-clinical decision making
Requirements
* Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
* Experience with primary liver cell isolation and functional characterization
* Experience working with mouse models of liver dysfunction
* Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
Nice to have
* History of contributing to a drug development program at the pre-clinical or clinical development stage
* Experience leading the design and execution of pre-clinical studies in mouse models
* Experience with single cell genomics methods
* Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)
-
Scientist, Metabolism
2 weeks ago
South San Francisco, United States NewLimit Full timeCompany infoNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...
-
Division of Endocrinology and Metabolism
2 weeks ago
San Francisco, United States University of California San Francisco Full timeApplication Window Open date: August 16, 2023 Next review date: Tuesday, Oct 31, 2023 at 11:59 pm (Pacific Time) Apply by this date to ensure full consideration by the committee. Final date: Sunday, Feb 16, 2025 at 11:59 pm (Pacific Time) Application Endocrinology, Physician, Scientist, Metabolism, Clinical Research, Diversity, Healthcare, Education
-
Postdoctoral Fellow, In Vivo Metabolism
2 weeks ago
San Francisco, United States California Life Company Full timePosition description: Calico is seeking a Postdoctoral Fellow who is excited to be part of a scientific team dedicated to unraveling the fundamentals of the aging process. We are looking for a scientist with a strong background in cellular and in vivo metabolism interested in applying this training to advance our understanding of the molecular mechanisms by...
-
Scientist, In Vivo Physiology
2 weeks ago
South San Francisco, United States NewLimit Full timeCompany info NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...
-
Scientist, In Vivo Physiology
2 weeks ago
South San Francisco, United States NewLimit Full timeCompany infoNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...
-
Job Staff Scientist
4 weeks ago
San Diego, California, United States WOLFRAM Full timeJob] Staff Scientist- Modeling & Simulation [Takeda] The Modeling and Simulation scientist will be responsible for modeling support for the Takeda portfolio in the preclinical translational (PKPD and Systems Pharmacology) group.Identifies and champions novel scientific approaches to develop innovative applications of modeling and simulation to biology,...
-
Associate Director of DMPK
3 weeks ago
San Francisco, United States EPM Scientific Full timeI am partnered with a growing biotech company located in San Francisco who is looking for an Associate Director of DMPK to join their team! This company currently has 8 candidates in their preclinical pipeline and 2 clinical candidates across metabolic, neuro, ophthalmology, and cardio areas. This is an exciting opportunity to become a DMPK representative...
-
San Diego, United States Viking Therapeutics Full timeread more " Purpose of Role: This position reports to the Vice President of pharmaceutical development. The associate research associate/scientist will contribute to the ongoing efforts to develop first-in-class or best-in-class therapies for metabolic and endocrine disorders. This is an excellent opportunity for a highly driven professional to contribute...
-
Principal Scientist Pharmacometrics
2 weeks ago
San Diego, United States International Staffing Consultants, Inc. Full timeTop Tier BioPharmaceutical company looking to add a Principal Scientist to their dynamic Pharmacometrics team. The Pharmacometrics Group applies a range of model informed drug development (MIDD) approaches to support early and late-stage development of small and large molecules. We are seeking a skilled and qualified industrial scientist who has experience...
-
Principal Scientist Pharmacometrics
2 weeks ago
San Diego, United States Crescent City Recruitment Group Full timeTop Tier BioPharmaceutical company looking to add a Principal Scientist to their dynamic Pharmacometrics team. The Pharmacometrics Group applies a range of model informed drug development (MIDD) approaches to support early and late-stage development of small and large molecules. We are seeking a skilled and qualified industrial scientist who has experience...
-
San Francisco, California, United States Nurix Therapeutics Full timeCompanyNurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries,...
-
Associate Director
3 weeks ago
South San Francisco, United States BioPhase Full timeAssociate Director$170-200K + bonus & equityResponsibilities:As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities include:Designing and executing in vitro and ex vivo studies to advance therapeutic...
-
Associate Director
4 weeks ago
South San Francisco, United States BioPhase Full timeAssociate Director$170-200K + bonus & equityResponsibilities:As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities include:Designing and executing in vitro and ex vivo studies to advance therapeutic...
-
Associate Director
1 month ago
South San Francisco, United States BioPhase Full timeAssociate Director$170-200K + bonus & equityResponsibilities:As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities include:Designing and executing in vitro and ex vivo studies to advance therapeutic...
-
Associate Director
3 weeks ago
South San Francisco, United States BioPhase Full timeAssociate Director $170-200K + bonus & equity Responsibilities: As the Associate Director you will play a pivotal role in establishing and expanding the company's capabilities for preclinical in vitro and clinical ex vivo disease pathobiology. Key responsibilities include: Designing and executing in vitro and ex vivo studies to advance therapeutic programs....
-
Senior Director, DMPK
4 weeks ago
San Diego, California, United States Vertex Pharmaceuticals, Inc Full timeVertex San Diego Drug Metabolism and Pharmacokinetics (DMPK) team is seeking a highly motivated, experienced scientist and leader Senior Director level to help advance discovery and development of transformational therapies for serious unmet medical needs.The Senior Director of Drug Metabolism & Pharmacokinetics will be part of the global DMPK and local site...
-
Associate Director Clinical Pharmacology
2 weeks ago
San Francisco, United States TANNER & ASSOC INC Full timeAssociate Director Clinical Pharmacology – San Francisco Biotech New Position: Associate Director Clinical Pharmacology – San Francisco Biotech Position Summary: The Associate Director role will have a broad range of responsibilities and oversight of programs in oncology, inflammation, and respiratory. This is a strategic role requiring appropriate...
-
San Diego, California, United States Eli Lilly and Company Full timeAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...
-
San Diego, California, United States Eli Lilly and Company Full timeAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...
-
San Diego, United States Eli Lilly and Company Full timeAt Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...