Scientist

2 weeks ago

Emeryville, United States 4D Molecular Therapeutics Inc. Full time

GENERAL SUMMARY:

As a Scientist in Vector Innovation you will contribute to improvements to our Therapeutic Vector Evolution platform primarily in novel AAV library design, production, and screening in support of the discovery of novel therapeutic AAV vectors. You will work closely with the entire Vector Innovation & Human Cell and Disease Modelling team onsite to ensure our platform continues to yield best in class novel AAV capsids.

RESPONSIBILITIES:

Lab Activities: 75% of TIME

* Design and generate new AAV capsid libraries using various diversification techniques
* Contribute to the improvement and execution of AAV capsid library screening and selection platform including NHP tissue processing, episomal recovery and sequencing
* Independently and effectively design and execute experiments to test new libraries and detection techniques
* Draft study designs, protocols, and maintain an electronic lab notebook
* Design and execute experiments to meet strict timelines
* Additional responsibilities defined by management

Cross Functional Meetings/Communication: 25% of TIME

* Contribute scientific ideas and knowledge in departmental and cross-functional team meetings
* Effectively present findings at departmental and cross-functional team meetings
* Engage in Vector Innovation study designs for various projects
* Present annually at Non-Clinical R&D meeting
* Help compile data and author reports for internal and external communication
* Communicate effectively with management and their team to achieve departmental and personal goals

QUALIFICATIONS:

Education:

* Ph.D. in a relevant scientific field, preferably Virology, Molecular Biology, Genetics or Biochemistry. Exceptional candidates with a Master's degree and/or significant experience in the AAV gene-therapy will also be considered.

Experience:

* 5+ years of experience within Biotech or similar industry or relevant academic experience
* 5+ years of experience in Molecular Biology and cell culturing
* Experience in the AAV gene therapy field is preferred

Technical Skills:

* Strong in molecular biology techniques, virus handling and transduction
* Solid background in library design, production, and high-throughput screening, with a preference for experience in RNA and DNA-based AAV library design and screening
* Knowledge about AAV biology, particularly AAV capsid binding, cell integration and localization to the nucleus
* Basic cell culture: adherent, suspension, transfection
* Protein identification through Western blotting, flow cytometry and immunocytochemistry
* Microscopy and use of imaging software
* NGS sequence analysis and bioinformatics experience is ideal but not necessary

Non-technical Skills

* Demonstrated ability to clearly convey complex scientific information to diverse audiences, both verbally and written
* Proven capability to work harmoniously within multidisciplinary teams, sharing knowledge and contributing to a positive team dynamic.
* Flexibility in responding to changes in priorities or projects and the ability to thrive in a fast-paced research environment.
* Creative and critical thinking skills to identify solutions to scientific challenges, with a willingness to explore various approaches.
* Strong time-management and prioritization skills, enabling efficient progress on multiple tasks or projects simultaneously.
* A commitment to precision in experimental design, data analysis, and documentation, ensuring the integrity and reliability of research findings.
* The resilience to persist through setbacks and challenges, maintaining focus on achieving long-term research goals.
* An eagerness to learn and stay informed about the latest developments and technologies in the field of AAV gene therapy.
* A strong sense of ethical responsibility and adherence to regulatory standards and safety protocols in research.
* Excellent ability to foster and maintain professional relationships, characterized by empathy, respect, and effective communication.

Base salary compensation range:

Bay Area Range: $130,000/yr - $154,000/yr

Please note that compensation varies on a variety of factors including experience, location, etc.

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