Associate Director, Bioinformatics

4 weeks ago

Watertown, United States Remix Therapeutics Full time
Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to patients. Remix has a commitment to demonstrate the highest levels of scientific integrity with urgency because those patients are counting on us to deliver. With an in-house technology platform built from scratch, we have rapidly generated multiple drug discovery programs that are advancing towards the clinic.

We seek a highly motivated, experienced translational bioinformatic leader to join our team located in Watertown, MA. As a translational bioinformatician reporting to the Head of bioinformatics and data science, this person will direct in collaboration with a cross-functional team of scientists and clinical experts the translational strategy and multi-omics analysis of complex data sets for the different projects leading to the development of novel RNA processing medicines. The ideal candidate will have a strong background in bioinformatics as well as translational expertise in one or more target areas relevant to Remix, especially oncology and/or neurodegeneration, and will be driven to succeed within a hypothesis-driven, team-oriented, and interdisciplinary biotech environment. The individual will be expected to contribute to all stages of drug development, supporting the translational efforts from the preclinical stage to marketing.

Principle duties and responsibilities:
  • Engage with the clinical and biomarker teams to organize and extract evidence of activity and other biological insights from emerging clinical data
  • Analyze complex multi-omics data sets across various modalities and connect insights and observations to clinical endpoints, highlighting possible indication expansion for key targets
  • Contribute to the translational computational strategy for a number of exciting early-and late-stage targets in the Remix portfolio, as well as partnered targets across diverse disease areas
  • Mine public and private multi-omic datasets including real-world data relating to Remix target areas for insights into patient stratification and biomarker strategies for early and late stage programs across Remix target areas, with a current focus on oncology and neurodegeneration
  • Work with internal groups at Remix as well as external partners to solve problems using cutting-edge data analysis and visualization
  • Participate and thrive in a culture of effective collaboration between experimental and computational scientists

Qualifications:
  • PhD in Computational Biology, Bioinformatics, or Computer Science, with 7+ years of total experience working in disease target areas relevant to Remix, especially oncology and/or neurodegeneration
  • Outstanding bioinformatics programming skills in at least one language relevant to data analysis such as Python or R
  • Ability to effectively communicate methodologies and results with colleagues, including bench scientists, research management, and project team leaders
  • Knowledge of RNA biology a plus, especially RNA splicing
  • Strong leadership skills
  • Strong problem-solving and troubleshooting skills
  • Ability to work in a dynamic and fast-paced environment independently and efficiently
  • Authorized to legally work in the US

Remix values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation, or any other legally protected status. Remix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Remix Therapeutics is not responsible for any fees related to resumes that are unsolicited.

  • Associate Director, Bioinformatics

    1 week ago

    Watertown, United States Remix Therapeutics Full time

    Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to...

  • Associate Director, Bioinformatics

    2 months ago

    Watertown, United States Remix Therapeutics Full time

    Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to...

  • Associate Director, Bioinformatics

    3 weeks ago

    Watertown, United States Remix Therapeutics Full time

    Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to...

  • Associate Director, Bioinformatics

    1 week ago

    Watertown, United States Remix Therapeutics Full time

    Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to...

  • Associate Director/Director, Trial Master File Management

    4 weeks ago

    Watertown, United States Planet Pharma Full time

    Location: Waltham, MA - 3 days / week onsite Salary: AD - $175K + 20% bonus; Director - $200K+ 22% Bonus Top Skills Proven ability to lead Trial Master File (TMF) strategy, streamline processes, oversee vendor management, and ensure inspection readiness. Strong background in managing vendors effectively. Extensive experience with inspection readiness and...

  • Real World Evidence-Associate Director

    2 weeks ago

    Watertown, United States AstraZeneca, plc Full time

    Gaithersburg, MD, Waltham, MA, or Mississauga, ON - Join AstraZeneca, a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the worlds Director, Evidence, Associate, Clinical, Healthcare, Data Scientist

  • Associate Director of Technical Accounting and SEC Reporting

    3 weeks ago

    Watertown, United States Planet Professional Full time

    Job Title : Senior Manager or Associate Director - Technical Accounting/SEC Reporting. Direct Hire Industry and Size: Growing, biotech company, 50+ employees. Exciting times ahead. Location: Watertown, MA Hybrid schedule (1-2 days in the office per week) Required: 4-5+ years SEC reporting/technical accounting experience biotech/life science industry CPA Info...

  • Associate Director, Drug Product, Process Development

    1 month ago

    Watertown, United States Tome Biosciences Full time

    At Tome, we are developing the next generation of programmable genomic integration technology. Our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are building an exceptional team and a work environment that is diverse, innovative, rewarding, and fun. We have an opportunity to re-write the patient story,...

  • Associate Director, Drug Product, Process Development

    1 week ago

    Watertown, United States Tome Biosciences Full time

    At Tome, we are developing the next generation of programmable genomic integration technology. Our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are building an exceptional team and a work environment that is diverse, innovative, rewarding, and fun. We have an opportunity to re-write the patient story,...

  • Associate Director of Technical Accounting and SEC Reporting

    3 weeks ago

    Watertown, United States Planet Professional Full time

    Job Title: Senior Manager or Associate Director - Technical Accounting/SEC Reporting. Direct Hire Industry and Size: Growing, biotech company, 50+ employees. Exciting times ahead. Location: Watertown, MA Hybrid schedule (1-2 days in the office per week) Required: 4-5+ years SEC reporting/technical accounting experience biotech/life science industry CPA ...

  • Associate Director, Procurement

    4 weeks ago

    Watertown, United States Alkermes Full time

    Job Description Alkermes seeks Associate Director of Procurement-Strategic Sourcing in Waltham MA. Manage global strategic sourcing activities, including develop/implement global strategic procurement plan for sourcing/management across multiple segments; lead/direct strategic sourcing activities; implement policies, best-practices, compliance reporting and...

  • Associate Director, Quality Systems

    1 month ago

    Watertown, United States Affini-T Full time

    About Affini-T Therapeutics Affini-T Therapeutics is an emerging biotechnology company focused on targeting oncogenic driver mutations with a "best-in-class" TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant diseases. Through the application of...

  • Associate Director, Quality Systems

    2 months ago

    Watertown, United States Affini-T Full time

    Job DescriptionJob DescriptionAbout Affini-T Therapeutics Affini-T Therapeutics is an emerging biotechnology company focused on targeting oncogenic driver mutations with a “best-in-class” TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant...

  • Associate Director, Quality Systems

    1 week ago

    Watertown, United States Affini-T Full time

    Job DescriptionJob DescriptionAbout Affini-T Therapeutics Affini-T Therapeutics is an emerging biotechnology company focused on targeting oncogenic driver mutations with a “best-in-class” TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant...

  • Associate Director, QC Analytics, Cell Therapy

    3 weeks ago

    Watertown, United States ElevateBio Full time

    ElevateBio is a technology-driven cell and gene therapy company, accelerating access to the cutting-edge technologies and expertise to change the future of medicine. Our integrated technologies model offers turnkey scale and biotechnological capabilities to power genetic medicines processes, programs, and companies to their full potential. The Role: The...

  • Associate Director, ADC Biology

    2 weeks ago

    Watertown, United States AstraZeneca, plc Full time

    Lead a team focused on cancer biology-based target discovery for ADCs. Collaborate with internal teams to prioritize targets, develop target identification and validation strategies. Support project teams with early validation work and exploration of Director, Biology, Development, Oncology, R&D, Associate, Management

  • Principal Scientist/ Associate Director

    3 weeks ago

    Watertown, Massachusetts, United States Entact Bio Full time

    Associate Director/Principal Scientist – Mass Spec based proteomics/chemical biologyAbout Us:Entact Bio is a preclinical stage biotechnology company developing a new class of drugs that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deubiquitinase (DUB) biochemistry, chemical biology, disease biology, and...

  • Principal Scientist/ Associate Director

    1 week ago

    Watertown, Massachusetts, United States Entact Bio Full time

    Associate Director/Principal Scientist – Mass Spec based proteomics/chemical biologyAbout Us:Entact Bio is a preclinical stage biotechnology company developing a new class of drugs that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deubiquitinase (DUB) biochemistry, chemical biology, disease biology, and...

  • Senior Manager/Associate Director, Regulatory Affairs

    5 days ago

    Watertown, United States People With Chemistry Full time

    Meet is working with a dynamic and innovative biopharmaceutical company dedicated to advancing Neuroscience therapies through cutting-edge research and development. They have a focus on improving patient outcomes, and are at the forefront of clinical trials that push the boundaries of medical science. They are actively hiring a Senior Manager/Associate...

  • Senior Manager/Associate Director, Regulatory Affairs

    1 week ago

    Watertown, United States People With Chemistry Full time

    Meet is working with a dynamic and innovative biopharmaceutical company dedicated to advancing Neuroscience therapies through cutting-edge research and development. They have a focus on improving patient outcomes, and are at the forefront of clinical trials that push the boundaries of medical science. They are actively hiring a Senior Manager/Associate...