Research Scientist I/II

1 month ago

Exton, United States Immunome Inc Full time
Job title: Research Scientist I/II

Location: Exton, PA

Reports To: Senior Director, Antibody Engineering

About Us:

Immunome is a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies. Our portfolio pursues each target with a modality appropriate to its biology, including immunotherapies, targeted effectors, radioligand therapies and antibody drug conjugates (ADCs). We believe that pursuing underexplored targets with appropriate drug modalities leads to transformative therapies. Our proprietary memory B cell hybridoma technology allows for the rapid screening and functional characterization of novel antibodies and targets.

Position summary:

We are seeking an enthusiastic Research Scientist I/II with experience in protein purification and characterization to join Immunome's Antibody Engineering group. This group supports mission-critical activities in both early phase research as well as lead discovery and optimization of antibody-based biologics. Therefore, the successful candidate will have opportunities to make meaningful contributions to programs at all levels of the research and early development spectrum. The RSI/II will support the production, purification, and characterization of recombinant proteins and antibodies. Working within a dynamic research environment, you will contribute to the advancement of various scientific projects by efficiently producing high-quality proteins for downstream applications. Your role will involve executing laboratory protocols, optimizing production processes, and ensuring the integrity and reproducibility of experimental results. Collaboration with cross-functional teams and adherence to laboratory safety protocols are essential aspects of this position. Prior industry/academic experience with cell culture, protein expression, and purification on AKTA or other chromatography instruments is a requirement. The ideal candidate will be interested in learning new assays and techniques to support the team's goals.

Key Responsibilities:
  • Perform protein expression and purification using mammalian, or other expression systems.
  • Execute established protocols to produce recombinant proteins, ensuring high yield and purity.
  • Troubleshoot and optimize production processes to improve efficiency and scalability.
  • Conduct analytical techniques such as SDS-PAGE, Western blotting, BLI, ELISA, and chromatography to assess protein quality and quantity.
  • Perform protein stability studies, including thermal denaturation, freeze-thaw, and aggregation analysis.
  • Maintain detailed laboratory records, including experimental protocols, data analysis, and observations.
  • Prepare technical reports, presentations, and summaries of experimental findings for internal use and regulatory submissions.
  • Work closely with cross-functional teams, including molecular biologists, biochemists, and analytical scientists, to support project objectives.
  • Communicate experimental plans, results, and interpretations effectively within the team and across departments.
  • Maintain laboratory equipment and ensure proper functioning through regular maintenance and calibration.
  • Adhere to laboratory safety protocols, including the handling of hazardous materials and the proper disposal of waste.
  • Contribute to the organization and cleanliness of the laboratory workspace.

Requirements

Educational background and experience: Bachelor's degree in molecular biology, biochemistry, immunology, or related discipline with 4+ years of industry experience OR MS with 2+ years of industry experience OR PhD with 0-2 years of experience in industry or academia.

Knowledge & Skills:
  • Protein purification experience
  • Ability to work in a collaborative professional environment
  • Strong positive attitude and motivation
  • Attention to detail, good oral and written communication
  • Mammalian cell culture experience

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

  • Research Scientist

    2 days ago

    Exton, United States Joulé Full time

    Job Title: Research Scientist Location: Exton, PA Type: 6 Month Contract to Direct Hire Start: Immediate Responsibilities: Perform protein expression and purification using mammalian, or other expression systems. Execute established protocols to produce recombinant proteins, ensuring high yield and purity. Troubleshoot and optimize production...

  • Senior Research Scientist, Antibody Engineering

    1 month ago

    Exton, United States Immunome Inc Full time

    Job title: Senior Research Scientist, Antibody EngineeringLocation: Exton, PAReports To: Senior Director, Antibody EngineeringAbout Us: Immunome is a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies. Our portfolio pursues each target with a modality appropriate to its biology, including immunotherapies,...

  • Scientist II, LCMS Bioanalysis

    3 weeks ago

    Exton, United States Pharmaron Full time

    Position Summary: Pharmaron (Exton) Lab Services LLC is seeking a candidate to join their LCMS Bioanalysis team. The Scientist II will play an integral role in growing the operations and customer base by supporting the analysis of various samples and performing studies/assays independently while delivering exceptional quality with a high attention-to-detail...

  • Associate Scientist/scientist

    1 month ago

    Exton, United States Frontage Lab Full time

    Associate Scientist/Scientist - Biologics Service FTE team Full Time Exton PA or Client's site at Spring House PA Frontage Laboratories Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to...

  • Scientist/ Senior Scientist-Genomics

    1 month ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Scientists and Scientists - GenomicsFull TimeLocation-Exton, PAFrontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China....

  • Scientist/ Senior Scientist-Genomics

    1 month ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionSenior Scientists and Scientists - GenomicsFull TimeLocation-Exton, PAFrontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China....

  • Associate Scientist/scientist

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionAssociate Scientist/Scientist – Biologics Service FTE teamFull TimeExton PA or Client’s site at Spring House PAFrontage LaboratoriesFrontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable...

  • Scientist/Associate Scientist- Biomarker

    1 month ago

    Exton, United States Frontage Lab Full time

    Frontage Laboratories: Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage's core competencies include drug metabolism, pharmokinetics/ pharmacodynamics...

  • Scientist/Associate Scientist- Biomarker

    1 month ago

    Exton, Pennsylvania, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionFrontage Laboratories:Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage's core competencies include drug metabolism,...

  • Scientist/Associate Scientist- Biomarker

    4 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionFrontage Laboratories:Frontage Laboratories Inc. (Frontage), is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage’s core competencies include drug metabolism,...

  • Scientist

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    **Scientist**: For a CRO (Frontage Laboratories, Inc. - Exton, PA): prepare dose formulations intended for pre-clinical animal studies in a GLP-compliant environment; identify suitable raw materials and technologies; generate and review study protocols; prepare and track dose formulation documentation; conduct method development and troubleshoot formulation...

  • Scientist

    2 weeks ago

    Exton, United States Frontage Laboratories Full time

    Scientist : For a CRO (Frontage Laboratories, Inc. – Exton, PA): prepare dose formulations intended for pre-clinical animal studies in a GLP-compliant environment; identify suitable raw materials and technologies; generate and review study protocols; prepare and track dose formulation documentation; conduct method development and troubleshoot...

  • Scientist (Group Leader)

    2 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist (Group Leader):For a CRO (Frontage Laboratories, Inc. - Exton, PA): plan, execute, and supervise product development experiments for complex drug product projects from pre-formulation design through Clinical Trial Material (CTM) manufacturing; write, review, and approve Pharmaceutical Development Report (PDR) for CTM...

  • Scientist/Senior Scientist

    3 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior Scientist - Cell Bioassay/Potency Title: Scientist/Sr. Scientist, Cell Bioassay/PotencyLocation: 760 Pennsylvania Drive, Exton, PA 19341Reports to: Sr Director BGC Therapy OperationsFull-timeFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization...

  • Scientist/Senior Scientist

    1 month ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Senior Scientist - Cell Bioassay/Potency Title: Scientist/Sr. Scientist, Cell Bioassay/PotencyLocation: 760 Pennsylvania Drive, Exton, PA 19341Reports to: Sr Director BGC Therapy OperationsFull-timeFrontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization...

  • Scientist/Senior Scientist

    3 weeks ago

    Exton, United States Frontage Lab Full time

    Scientist/Senior Scientist Full-Time Exton PA Frontage Laboratories Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout the drug discovery and development process to enable life science companies to achieve their drug development goals. We have enabled many...

  • Scientist (Bioassay)

    4 weeks ago

    Exton, United States Pharmaron Full time

    **Pharmaron (Exton)** is seeking a talented Scientist who will work as part of a team to complete client/Sponsor driven projects. **Primary Responsibilities**: - Leading development and Validation of new assays including Gxp assays - May be serving as Principal Investigator (PI) for multiple projects as assigned - Contributing to study design, execution,...

  • Associate Scientist

    1 month ago

    Exton, United States Frontage Lab Full time

    Associate Scientist/Scientist- Cell-Based Assay Core Facility Title: Associate Scientist/Scientist Location: Exton PA Reports to: Associate Director, Core lab of Cell-based assay Full-time Frontage Laboratories Frontage Laboratories is a CRO / Clinical Research Organization providing integrated, science-driven, product development services throughout...

  • Scientific Account Management Liaison

    1 month ago

    Exton, United States RPM ReSearch Full time

    Job DescriptionJob DescriptionLocation: Greater Philadelphia Area, Pennsylvania Title: Scientific Account Manager, Drug Development ServicesProduct or Service: Drug development services for ADME, drug transporters, drug metabolism, pharmacokinetics, toxicokinetics, and/or bioanalytical method development Bioanalysis Services and Study DesignPreclinical...

  • Scientist

    1 month ago

    Exton, United States Frontage Lab Full time

    Scientist-Automation Full Time Location-Exton, PA Frontage Laboratories Inc. (Frontage) is a global contract research organization with broad expertise in supporting pre-clinical and clinical drug development. Frontage operates out of several different locations within the USA, Canada, and China. Frontage's core competencies include drug metabolism,...