Research Scientist

3 weeks ago

Tampa, United States Moffitt Cancer Center Full time

At Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 are dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated. For this reason, Moffitt has been recognized on the 2023 Forbes list of America's Best Large Employers and America's Best Employers for Women, Computerworld magazine's list of 100 Best Places to Work in Information Technology, DiversityInc Top Hospitals & Health Systems and continually named one of the Tampa Bay Time's Top Workplace. Additionally, Moffitt is proud to have earned the prestigious Magnet designation in recognition of its nursing excellence. Moffitt is a National Cancer Institute-designated Comprehensive Cancer Center based in Florida, and the leading cancer hospital in both Florida and the Southeast. We are a top 10 nationally ranked cancer center by Newsweek and have been nationally ranked by U.S. News & World Report since 1999.

Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join our committed team and help shape the future we envision.

Summary

Research Scientist - Chemical Proteomics

The Ideal Candidate:

We are seeking a highly motivated and talented Research Scientist to join our team, focusing on target identification by chemical proteomics. The Research Scientist will play a crucial role in advancing our understanding of potential cancer drug targets identified through fragment-based drug discovery screens and chemical proteomics. This position offers a unique opportunity to contribute to translational research and the development of novel therapies for cancer treatment.

Responsibilities:

* Identification of Drug Targets:
* Utilize cell biology techniques to assess the impact of different compound analogues on cancer cell behavior, proliferation or survival.
* Design and execute click-chemistry facilitated chemical proteomics experiments to identify target proteins of compounds selected from fragment-based drug discovery screens.
* Process samples for mass spectrometry-based proteomics analysis.
* Visualize proteins by fluorescence imaging and Western blot analysis.


* Experimental Design and Optimization:
* Collaborate with medicinal chemists to design and implement linker strategies tailored to specific screening hits.
* Develop and optimize protocols for chemical proteomics experiments in collaboration with core staff.


* Data Analysis and Interpretation:
* Analyze and interpret proteomics data to identify and prioritize drug targets.
* Collaborate with bioinformaticians to integrate proteomics results with other data sets for a comprehensive analysis.


* Collaboration and Communication:
* Work collaboratively with multidisciplinary teams, including proteomics, medicinal chemistry, molecular biology, bioinformatics, and preclinical development.
* The candidate will work closely within the team to facilitate downstream processing for genetic validation experiments.
* Present findings at internal meetings, conferences, and contribute to publications.


* Cell Line and Model Maintenance:
* Maintain cancer cell lines for compound prioritization and chemical proteomics experiments.


* Instrumentation and Technology:
* Operate and maintain cutting-edge laboratory equipment and technologies related to affinity enrichment, sample processing and protein visualization.
* Stay abreast of advancements in the field and recommend the integration of new technologies .



Credentials and Qualifications:

* Minimum of three (3) years postdoctoral fellow or post PhD science experience in Chemical Biology, Biochemistry, Cancer Biology, Molecular Biology, or a related field is required.
* Proven expertise in proteomics and affinity purification, particularly in the context of cancer biology.
* Strong biochemistry skills, as well as mass spectrometry data analysis.
* Excellent organizational, analytical, and communication skills.
* Ability to work collaboratively in a team-oriented environment.

How to Apply: Interested candidates should submit their online application, additionally include a cover letter, curriculum vitae, and contact information for three references to derek.duckett@moffitt.org and Uwe.Rix@moffitt.org. Please include "Research Scientist - Chemical Proteomics" in the subject line.

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