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Scientist, Medicinal Chemistry

4 months ago

Boston, United States Jnana Therapeutics Full time
About Us

Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune mediated diseases. Jnana's wholly owned lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, a highly experienced management team, and the backing of leading life science investors Bain Capital Life Sciences, RA Capital Management, Polaris Partners, Versant Ventures, Avalon Ventures, Pfizer Ventures, and AbbVie Ventures. For more information, please visit www.jnanatx.com and follow us on Twitter/X and LinkedIn .

About the OpportunityJnana Therapeutics is looking to add future chemistry capabilities to the team and seeking to proactively network with enthusiastic entry level medicinal chemists that will be receiving their Ph.D. or completing a post doc this year.

This individual will support our internal chemistry group focused on drug discovery programs for hard-to-drug targets. Through small molecule screening using our novel and proprietary chemoproteomics RAPID platform, our research aims to identify novel small molecules against these challenging targets to interrogate target biology and ultimately to develop drug candidates that can provide clinical value to patients.

Responsibilities
  • Utilize synthetic expertise to design and execute synthesis of target molecules
  • Work closely with external chemistry CRO teams to synthesize and screen target molecules
  • Work collaboratively across scientific disciplines on multiple projects
  • Proactively engage in brainstorming and the generation of new ideas across projects
  • Assist in preparing patent applications and publications
  • Maintain a safe and productive laboratory environment
  • Help to build and expand an innovative platform for drug discovery
  • Develop a foundation of medicinal chemistry principles and basic drug discovery design skills

Preferred Qualifications & Past Experience
  • Ph.D. and/or post-doc experience in Medicinal Chemistry, Organic Chemistry, or closely related field with 0-2 years industry experience as a medicinal chemist
  • Passion for drug discovery, highly-organized and excellent communication skills