Associate Director, Pharmacometrics

1 month ago


Wilmington, United States InCyte Full time

Overview

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

We are seeking an experienced and talented Pharmacometrician to join our Clinical Pharmacology & Pharmacometric organization in Translational Medicine. This individual will contribute to drug development from Phase I FIH to LCM as an emerging leader in the Pharmacometric field. You will be responsible for all aspects of Pharmacometric analyses for a range of programs and a 'go to' expert within the company for aspects of quantitative clinical pharmacology.

Essential Functions of the Job (Key responsibilities)

* Contribute to Clinical PK & Clinical Pharmacology plans in collaboration with CPP leads and project teams.
* Execute the pharmacometric analyses, such as PKPD, PPK, exposure-response, tumor growth dynamic modeling, or PBPK analyses, and interpret the results to recommend dosing paradigm for different phases of clinical development; contribute to the justification for dose selection for pivotal clinical trials.
* Liaise with CPP leads, Clinical Biomarker leads, and preclinical scientists to come up with fit-for-purpose models pertinent to the clinical development; collaborate with BioStats, Data Management, Clinical Operations & Medical and have an impact on development projects
* Generate reports for PK/PD analyses, population PK, exposure-response analyses, clinical trial simulations, comparator modeling, or PBPK analyses.
* Have a general understanding of global regulatory guidance on various pharamcometrics analyses and reporting.
* Present data and recommendations to project teams, external collaborators and senior management.
* Publish in peer reviewed journals.

Qualifications (Minimal acceptable level of education, work experience, and competency)

* Ph.D. in an appropriate discipline that lays the foundation for the job functions detailed above; strong background in mathematics/statistics and a deep understanding of molecular pharmacology.
* Hands on experience with NONMEM, R, Phoenix, Monolix, SimCYP, GastroPlus, Matlab, or other programs
* Hands on experience with PK/PD, pop PK, ER, or PBPK.
* 7-10 years or more of related industry and/or FDA experience.
* Experience working in a matrix environment.
* Appropriate publication record is required.



  • Wilmington, DE, United States Incyte Full time

    Apercu Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care,...


  • Wilmington, United States University of North Carolina Wilmington Full time

    UNCW is wrapping up the public phase of a $125 million comprehensive campaign, and the Office of Annual Giving is growing its team to better serve the needs of University Advancement. The Associate Director of Annual Giving will serve as a trusted pa Director, Associate, Education, Clinical Research, Business Services, Program, Support


  • Wilmington, United States Carmichael Lynch Full time

    We are seeking an Associate Media Director to join our team. Role: The Associate Media Director is responsible for the daily management of assigned accounts and media teams.This role oversees the development, presentation, implementation and optimization of the Media strategy within the framework of the overall plan.This role is the key facilitator of...


  • Wilmington, United States Annual Giving Network Full time

    UNCW is wrapping up the public phase of a $125 million comprehensive campaign, and the Office of Annual Giving is growing its team to better serve the needs of University Advancement. The Associate Director of Annual Giving will serve as a trusted partner to the Director of Annual Giving and will be responsible for managing many of the day-to-day operations...


  • Wilmington, United States Annual Giving Network Full time

    UNCW is wrapping up the public phase of a $125 million comprehensive campaign, and the Office of Annual Giving is growing its team to better serve the needs of University Advancement. The Associate Director of Annual Giving will serve as a trusted partner to the Director of Annual Giving and will be responsible for managing many of the day-to-day operations...


  • Wilmington, United States AstraZeneca, plc Full time

    Are you ready to make a significant impact on patient lives? AstraZeneca is seeking an Associate Marketing Director for our Inhaled Respiratory division within the Biopharmaceuticals Business Unit. This role offers the opportunity to shape the future Director, Respiratory, Associate, Marketing, Pharmaceutical Sales, Marketing Director, Business Services


  • Wilmington, United States University of North Carolina Wilmington Full time

    Brief Summary of Work for this Position The Associate Director of Fraternity and Sorority Life serves as part of a team supporting, advising and advocating for a community comprised of four governing councils, 30+ nationally affiliated chapters and colonies made up of approximately 1,500 total students (10% of undergraduates). Reporting to the Director...


  • Wilmington, United States AstraZeneca, plc Full time

    At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. AstraZeneca is looking to hire an Associate Director, Data Management Operations Operations, Director, Management, Associate, Operation, Pharmaceutical Sales, Manufacturing


  • Wilmington, United States National Black MBA Association Full time

    Are you ready to make a big impact? AstraZeneca is at an exciting time of new products and launches of cutting-edge medicines that change people’s lives We develop, manufacture and supply innovative scientific products, delivered through our ground-breaking global supply chain, using the latest technologies and modern facilities. There's a great...


  • Wilmington, United States National Black MBA Association Full time

    Are you ready to make a big impact? AstraZeneca is at an exciting time of new products and launches of cutting-edge medicines that change people’s lives We develop, manufacture and supply innovative scientific products, delivered through our ground-breaking global supply chain, using the latest technologies and modern facilities. There's a great...

  • Associate Director

    4 weeks ago


    Wilmington, United States Stoltz Management of Delaware Full time

    Position: Associate Director Department: Capital Markets Supervisor: Co-CEO & Chief Operating Officer JOB SUMMARY: Real Estate private equity firm with extensive holdings throughout the U.S. is seeking a self-motivated and talented Associate Director to join its Philadelphia investment team. The Associate Director will be actively involved in acquisitions,...


  • Wilmington, United States AstraZeneca Full time

    Job DescriptionJob Title: Associate Director, Market Research - AmericasIntroduction to role:Join us in the exciting role of Associate Director, Market Research - Americas, where you will be a key player in the Americas Procurement Category team. Reporting to the Director Category Management Americas, you will engage with the Global Procurement Category Team...


  • WILMINGTON, United States OneMain Financial Full time

    Position: Associate Director, ExecutionLocation: Wilmington, DE; Baltimore, MD (hybrid)  We are currently seeking a Associate Director for our Execution team in Wilmington, DE. This role will have the exciting opportunity to learn and drive significant business results by coding and executing strategies that inform critical business decisions. This...


  • Wilmington, United States AstraZeneca Full time

    Job DescriptionJoin us at AstraZeneca, where we turn ideas into life-changing medicines. As an Associate Director in Promotional Regulatory Affairs, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. In conjunction with the TA Senior Director, Respiratory & Immunology...


  • Wilmington, DE, United States Calcium+Company Full time

    Job Description ASSOCIATE MEDICAL DIRECTOR Medical Strategy Department Reports to: EVP, Medical Director Job Summary The Associate Medical Director will be responsible for reviewing different therapeutic areas, published clinical trials, and data to develop the appropriate medical communication, whether in PowerPoint or Word formats, to support the...


  • Wilmington, United States Thomas Jefferson University Hospital Full time

    Associate Director, Annual Giving ¿ Direct Response Under the leadership of the Assistant Vice President (AVP) of Annual Giving, the incumbent will write, manage and implement direct response programs focused on acquiring or increasing annual support from alumni, alumni family members, grateful patients and friends on behalf of Jefferson. Additionally, the...


  • Wilmington, United States AstraZeneca Full time

    Job DescriptionJoin AstraZeneca, where we turn ideas into life-changing medicines. We are seeking an entrepreneurial, big-thinking Associate Director for HCP Marketing in our Biopharmaceuticals Business Unit. This role is responsible for the development and implementation of go-to-market plans, execution, and measurement aligned to brand strategic...


  • Wilmington, DE, United States OneMain Financial Full time

    Position: Associate Director, Execution Location: Wilmington, DE; Baltimore, MD (hybrid) We are currently seeking a Associate Director for our Execution team in Wilmington, DE. This role will have the exciting opportunity to learn and drive significant business results by coding and executing strategies that inform critical business decisions. This...


  • Wilmington, United States Adaptimmune Full time

    Adaptimmune is a fully integrated cell therapy company, designed and built from the ground up with four U.K.- and U.S.-based biotechnology hub locations. Our comprehensive capabilities and teams include preclinical research, clinical development, translational sciences, autologous and allogeneic manufacturing, and in-house commercial and corporate...

  • HR Director

    2 weeks ago


    Wilmington, United States Bedrock Care Full time

    Human Resources Director Full-time About Us: Cliveden Rehabilitation and Nursing Center is a 180-bed skilled facility offering short-term rehabilitation and long-term care services. Our staff is committed to providing excellent care and services in a friendly, resident-focused, home-like environment. We are currently seeking a qualified individual to join...