Senior/Research Associate, Metabolism

3 weeks ago


South San Francisco, United States NewLimit Full time

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking a Senior/Research Associate with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease.

In this role, you will perform in vivo and ex vivo assays for hepatocyte function and collaborate with our Epigenetic Editing and Single Cell Technology teams to deliver reprogramming factors to hepatocytes and measure their phenotypic effects.

What you'll do

* Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
* Isolate murine and human hepatocytes using perfusion, FACS, and gradient based approaches
* Reprogram hepatocytes ex vivo and in vivo
* Perform experiments in pre-clinical liver disease animal models
* Perform functional and phenotypic assays to evaluate the effects of reprogramming on hepatocyte biology

Requirements

* BS in cell biology, endocrinology, molecular biology, or a related natural science and 2+ years of work experience in a cell/molecular biology laboratory (academic or industry setting) or PhD in cell biology, endocrinology, molecular biology, or a related field
* Proficiency in animal handling and husbandry techniques for rodent models (mice or rats)
* Proficiency with mammalian cell culture
* Exceptional organizational skills, as demonstrated by detailed record-keeping in lab notebook and an ability to effectively carry out multiple ongoing projects or experiments

Nice to have

* Proficiency in molecular biology and molecular cloning methods
* Experience working with mouse models of liver dysfunction
* Experience with ex vivo culture and manipulation of hepatocytes
* Experience with single cell genomics methods



  • South San Francisco, United States NewLimit Full time

    Company infoNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...


  • South San Francisco, United States Bayside Solutions, Inc. Full time

    Bayside Solutions is seeking a Senior Research Associate to be part of our client' s team in South San Francisco. This is an opportunity to work with the largest privately held pharmaceutical corporation in the world and ranks among the world' s 20 l Research, Associate, Senior, Technology, Staffing, Pharmaceutical, Benefits, Biology


  • South San Francisco, United States Warman O’Brien Full time

    Senior Research Associate/Associate Scientist | Onsite | Permanent | Competitive Salary Start Date: ASAP Location: South San Francisco   What’s it Like to Work Here?   My client, a growing biotech company at the forefront of biotechnology innovation, are in search of a senior research associate/ associate scientist. You will get...


  • South San Francisco, United States Warman O'Brien Full time

    Senior Research Associate/Associate Scientist | Onsite | Permanent | Competitive Salary Start Date: ASAPLocation: South San FranciscoWhat’s it Like to Work Here? My client, a growing biotech company at the forefront of biotechnology innovation, are in search of a senior research associate/ associate scientist. You will get to work on the cutting edge of...


  • South San Francisco, United States Warman O'Brien Full time

    Senior Research Associate/Associate Scientist | Onsite | Permanent | Competitive Salary Start Date: ASAPLocation: South San FranciscoWhat’s it Like to Work Here? My client, a growing biotech company at the forefront of biotechnology innovation, are in search of a senior research associate/ associate scientist. You will get to work on the cutting edge of...


  • South San Francisco, United States Warman O'Brien Full time

    Senior Research Associate/Associate Scientist | Onsite | Permanent | Competitive Salary Start Date: ASAPLocation: South San FranciscoWhat’s it Like to Work Here? My client, a growing biotech company at the forefront of biotechnology innovation, are in search of a senior research associate/ associate scientist. You will get to work on the cutting edge of...


  • San Francisco, United States California Life Company Full time

    Position description: Calico is seeking a Postdoctoral Fellow who is excited to be part of a scientific team dedicated to unraveling the fundamentals of the aging process. We are looking for a scientist with a strong background in cellular and in vivo metabolism interested in applying this training to advance our understanding of the molecular mechanisms by...


  • South San Francisco, United States Skills Alliance Full time

    About the roleOur client is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. We are looking for a 5-month contractor Research Associate/Senior Research Associate/Principal Research Associate to join the Analytical...


  • South San Francisco, United States Skills Alliance Full time

    About the roleOur client is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. We are looking for a 5-month contractor Research Associate/Senior Research Associate/Principal Research Associate to join the Analytical...


  • South San Francisco, United States Skills Alliance Full time

    About the roleOur client is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. We are looking for a 5-month contractor Research Associate/Senior Research Associate/Principal Research Associate to join the Analytical...


  • San Francisco, United States Veterans Health Research Institute Full time

    Position Definition: The Staff Research Associate I is responsible for participating in the day-to-day operations of routine, minimally complex clinical research programs and/or studies conducted by Principal Investigators (PIs) at the San Francisco VA. Performs a variety of administrative and operational duties involved in the collection, compilation,...


  • South San Francisco, United States Cytokinetics, Incorporated Full time

    Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of...

  • Senior Researcher

    3 weeks ago


    South San Francisco, United States BEPC Inc. - Business Excellence Professional Consulting Full time

    BEPC has an open position for a Research Associate III in South San Francisco, CA!!Contract W2 Period: 12month contract with possibilities for extensions.Pay & Benefits: $43-$50/hr. + Medical, Dental, Vision and Life InsuranceThe mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed...

  • Senior Researcher

    3 weeks ago


    South San Francisco, United States BEPC Inc. - Business Excellence Professional Consulting Full time

    BEPC has an open position for a Research Associate III in South San Francisco, CA!!Contract W2 Period: 12month contract with possibilities for extensions.Pay & Benefits: $43-$50/hr. + Medical, Dental, Vision and Life InsuranceThe mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed...


  • San Francisco, California, United States Nurix Therapeutics Full time

    CompanyNurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries,...


  • San Francisco, United States University of California San Francisco Full time

    Application Window Open date: August 16, 2023 Next review date: Tuesday, Oct 31, 2023 at 11:59 pm (Pacific Time) Apply by this date to ensure full consideration by the committee. Final date: Sunday, Feb 16, 2025 at 11:59 pm (Pacific Time) Application Endocrinology, Physician, Scientist, Metabolism, Clinical Research, Diversity, Healthcare, Education

  • Research Associate

    3 weeks ago


    South San Francisco, United States Seranova Bio Full time

    Seranova Bio, an early-stage biotechnology leader, is recruiting for a Senior Research Associate role. This role offers the opportunity to join a team working on exciting first-in-class biologics across multiple therapeutic areas, leveraging our cutting-edge REAP technology and analytics platform.About Seranova BioSeranova Bio is an early-stage company...

  • Research Associate

    3 weeks ago


    South San Francisco, United States Seranova Bio Full time

    Seranova Bio, an early-stage biotechnology leader, is recruiting for a Senior Research Associate role. This role offers the opportunity to join a team working on exciting first-in-class biologics across multiple therapeutic areas, leveraging our cutting-edge REAP technology and analytics platform.About Seranova BioSeranova Bio is an early-stage company...

  • Research Associate

    3 weeks ago


    South San Francisco, United States Seranova Bio Full time

    Seranova Bio, an early-stage biotechnology leader, is recruiting for a Senior Research Associate role. This role offers the opportunity to join a team working on exciting first-in-class biologics across multiple therapeutic areas, leveraging our cutting-edge REAP technology and analytics platform.About Seranova BioSeranova Bio is an early-stage company...


  • San Francisco, United States Northern California Institute for Research and Education Full time

    Position Definition: The Staff Research Associate I is responsible for participating in the day-to-day operations of routine, minimally complex clinical research programs and/or studies conducted by Principal Investigators (PIs) at the San Francisco VA. Performs a variety of administrative and operational duties involved in the collection, compilation,...