Scientist - Immunoassay and Biomarker Development

3 weeks ago

Framingham, United States Berg Health Full time
POSITION SUMMARY:

The Scientist - Immunoassay and Biomarker Development's primary focus is on immunoassay development, screening, and biomarker projects.

ESSENTIAL DUTIES AND RESPONSIBILITIES:
  • Assist in ligand binding assay method development (MSD, ELISA) and provide technique and application support for immunoassays transferred to downstream users.
  • Test antibody quality for purity (SDS-PAGE), specificity (Western Blot, ELISA), and concentration (Nanodrop, BCA).
  • Conduct assay performance validation.
  • Conduct compound screening utilizing the developed assays.
  • Develop pharmacodynamic biomarker assays to support internal clinical development.
  • Perform protein analysis (SDS/native-PAGE, Western Blot, and Immunoprecipitation).
  • Develop experiment protocols and prepare SOPs.
  • Perform and manage cell culture experiments for MOA, PD biomarker mechanistic insight, as well as biomarker assessment.
  • Perform laboratory experiments carefully and troubleshoot to solve problems.
  • Meticulously document experiment results in laboratory notebooks and databases timely.
  • Analyze, summarize, and present experimental results to managers and other team members.
  • Prepare experiment and project reports as required.
  • Order and stock laboratory supplies for a continuous and consistent workflow.
  • Other duties, as assigned.

REQUIREMENTS:
  • Requires a PhD (1-3 years' experience) or MS (4-7 years) in biology/biochemistry/chemistry/immunology.
  • Knowledge and prior experience with protein analytical methods, such as ELISA, Protein concentration assays, SDS-PAGE, Western Blot and mass spectrometry (a plus).
  • Prior experience managing cell culture experiments for MOA and biomarker assessment.
  • Qualified applicants must have good pipetting skills, be analytical and flexible.

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