Director of Peptide Chemistry and Formulation

4 weeks ago

Culver City, United States NantWorks, LLC Full time
NantWorks (the "Company") is the parent company of various private and public entities that are changing how we work, live and play. We focus on three main categories: life sciences; energy & renewables; and media & technology. We invest in strategies that improve our core capabilities and in brand new industries, poised to change mankind for the better. By capturing tomorrow's opportunities through scientific processes and entrepreneurial philosophies, we are at the forefront of emerging high-growth technologies across a wide range of industries.

The Company is a mandatory vaccination employer for COVID-19 and its variants. The Company requires that its employees be fully vaccinated as of their start date. If you require a medical or religious accommodation we will engage in the interactive process with you. Proof of vaccination will be required prior to start. If we make you an offer and you are not yet vaccinated, we will accommodate a delay in start date. The Companymay also mandate that its employees receive vaccine boosters, and all accommodation laws will be followed.

Position Summary:

ConjuChem creates novel, next-generation medicines using unique, long-acting therapeutic peptides. Underlying all ConjuChem compounds are bioconjugation platforms called Drug Affinity Complex (DAC™) and Preformed Conjugate-Drug Affinity Complex (PC-DAC™). When applied to a given peptide, DAC™ and PC- DAC™ can create new drugs with similar therapeutic activities but with significantly longer durations of activity and improved safety profiles.

The Director of Peptide Chemistry and Formulation will be responsible for leading new peptide drug development and new formulation for the peptide drugs

Responsibilities:
  • Responsible for peptide synthesis, purification, lyophilization, conjugation.
  • Provide direction in therapeutic peptide drug development, target identification to candidate selection of peptide drugs, as well as contribute to research activities in support of CTA/IND submissions.
  • Provide direction and strategy in formulation development of current company on going anti diabetes and anticancer drugs.
  • Lead a team to develop a long-acting peptide drug.
  • Help to establish R&D scale and manufacturing scale in peptide drug development.
  • Closely interact with analytical department and non-clinical department to assist the drug characterization and MOA.
  • partnering with other preclinical functional groups, with program management, and other internal functions, as well as external collaborators and consultants, to achieve research milestones culminating in successful IND-filings.
  • Effective internal and external scientific communications (e.g. reports, regulatory documents, research publications).

Requirements:
  • Ph.D. in Peptide chemistry and formulation, at least 10 years experience in peptide drug research.
  • With at least 10 years working experience in peptide research and drug formulation, and protein conjugation.
  • experience operating and maintaining peptide synthesizers.
  • experience with conjugation of therapeutic peptide with recombinant human albumin.
  • experience with purification of synthesis peptides, conjugation, and lyophilization.
  • experience supervising and directing a formulation team to develop a long-acting peptide drug and oral peptide drug.

Salary: 150,000 to 175,000 annually

This is the pay range the Company reasonably expects to pay for this position at the time of this posting. Compensation will be determined based on the skills, qualifications, and experience of the applicant along with the requirements of the position.

We offer competitive benefits, including health, dental and vision insurance, 401k, short-term and long-term disability insurance, life insurance, 11 designated holidays, Paid Time-Off program, and Employee Assistance Program.

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