Head of Biochemistry and Biophysics

2 weeks ago

Cambridge, United States MOMA Therapeutics Full time

MOMA Therapeutics is looking for an experienced Head of Biochemistry and Biophysics

Imagine joining a company where you….

* Will be part of an experienced and resilient team that is collectively unstoppable, trusts one another, and selflessly collaborates
* Will work with incredible humans who are committed to the discovery of transformative medicines for patients
* Are needed… because patients are counting on you

About MOMA Therapeutics

MOMA Therapeutics is a biotechnology company focused on developing inhibitors of highly dynamic proteins, namely ATPases, which play critical roles in a variety of Oncology indications. Our platform allows us to successfully prosecute drug discovery against difficult and unprecedented targets which are core cancer dependencies. MOMA is planning to initiate clinical development for two programs in 2024.

In this role… you will provide leadership and vision to MOMA's biochemistry and biophysical research group. The successful candidate will bring a strong background in small molecule drug discovery and a deep understanding of the key role biochemistry plays across all stages of the process. This individual will lead the biochemistry and biophysics team and be responsible for the development of strategy and implementation of all aspects of the biochemical and biophysical contributions to our drug discovery programs, integration of biochemistry across structural biology, computational chemistry, medicinal chemistry, and cellular pharmacology, and driving compound management, tracking and inventory. Additionally, this individual will play a key role in new target identification and the continued development of MOMA's platform. The individual should possess strong leadership skills and core competency in modern biochemical and biophysical techniques.

Key responsibilities include…

* Provide leadership and strategic vision for the biochemistry function in support of MOMA's small molecule drug discovery programs.
* Develop and implement strategies to leverage biochemical and biophysical characterization to guide SAR development.
* Provide biochemistry perspective as part of a strong multi-disciplinary drug discovery team that includes computational chemistry, structural biology, medicinal chemistry, and cell biology expertise.
* Contribute to the development of MOMA's new target identification and platform build.
* Coordinate and integrate ancillary functions such as compound management, automation, and data analysis.
* Manage scientists with special emphasis on scientific mentoring and career development.
* Drive efficient and effective collaborations with contract research organizations and academic collaborators.

About you…

* This position requires a PhD degree in biochemistry or a related discipline and at least 10 years of relevant experience in a biopharmaceutical research setting.
* Experience successfully applying appropriate biochemical and biophysical platforms to support hit characterization, MOA elucidation and SAR development; experience with hit finding approaches for development of allosteric inhibitors highly preferred.
* Demonstrated experience in all stages of small molecule drug discovery; experience in oncology preferred.
* Demonstrated experience functioning within a strong multi-disciplinary team, utilizing cross-functional information, such as structural and cell biology data, to optimize the biochemical workflow.
* Experience in the management and development of scientists.
* Demonstrated experience in complex problem solving through in-depth analysis of data and situations.
* Demonstrated experience working with contract research organizations and academic collaborators.
* Strong interpersonal and communication skills, a demonstrated ability to lead and motivate others, and enthusiasm for participating in a fast-paced environment characterized by rigorous science and innovative thinking.

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