Associate Principal Scientist, Project Representative

1 month ago


Boston, United States Merck Full time

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified itslegacy for over a century. Our company’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives.Every employee is building on our proudlegacy of scientific breakthrough.Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team.We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration.At our Research Labs in Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Associate Principal Scientist to contribute to our small molecule and peptide drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our research division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional teams through strategic design of discovery testing funnels, generation and interpretation of PK and PK/PD data sets and through effective communication at both internal meetings and external conferences.

In this exciting position, your primary roles will include:

  • Project-team representative and subject matter expert on small molecule and/or peptide-based DMPK activities within the oncology and immunology therapeutic areas

  • Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeutics

  • Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safety

  • Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates

Education Minimum Requirement

  • Ph.D (with 3+ years relevant experience), Master’s (minimum of 6 years relevant experience), or Bachelor's (minimum of 12+ years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field

  • Relevant experience to include a record of increasing responsibility and independence in a similar industrial/applied academic setting

Experience and Skills (Highly preferred, must have 3/4 of listed technical skills):

  • Demonstrated experience leading small molecule or peptide DMPK discovery efforts as an independent project-team representative within a highly collaborative environment

  • Ability to design, optimize and interpret DMPK-related optimization strategies (discovery testing funnels) as part of a broader research operating plan

  • Technical ability to analyze, interpret and provide context around data describing the ADME, pharmacokinetic and pharmacodynamic properties of small molecules or peptides, including use of software such as Phoenix WinNonlin

  • Experience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting

  • Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment

Preferred Experience and Skills

  • Hands-on experience performing translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB).

  • Ability to design and interpret novel, hypothesis-driven ADME and bioanalytical strategies (primarily LC/MS) to support the optimization of small molecule and peptide therapeutics

  • Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling efforts

  • Familiarity with structure-activity relationships aimed at improving pharmacokinetic and pharmacodynamic properties of small molecules or peptides

  • Experience working within a research-driven pharmaceutical company

#EligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

11/22/2024

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

#J-18808-Ljbffr

  • Boston, United States Merck Sharp & Dohme Full time

    Job Description Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company’s...


  • Boston, United States Pristine Infotech Full time

    Principal AI Scientist Location: Boston Role: Principal AI ScientistExperience: 3 to 5 yearsQualification: PhD in AI, Comp Science, Math or Stats from exceptional institutions Can you architect real-time optimized recommendation engines leveraging cognitive, prescriptive, explainable AI? Can you develop self-learning models? Can you envision automating...


  • Boston, United States Wood Mackenzie Full time

    In the middle of the energy transition, businesses and governments are faced with significant challenges. But the pace and scale of change mean every decision is made under mounting pressure. Now, more than ever, companies need reliable data, analytics and actionable insight. Wood Mackenzie is the leading global provider of data and analytics solutions for...


  • Boston, United States Amazon Full time

    Principal Applied Scientist, AGI AutomationsJob ID: 2849765 | Amazon.com Services LLCThe Artificial General Intelligence (AGI) team is looking for a passionate, talented, and innovative principal applied scientist with a strong background in deep learning, to help build industry-leading technology with Large Language Models (LLMs) and multimodal systems.Key...


  • Boston, United States Amazon Full time

    Principal Applied Scientist, AGI AutomationsJob ID: 2849765 | Amazon.com Services LLCThe Artificial General Intelligence (AGI) team is looking for a passionate, talented, and innovative principal applied scientist with a strong background in deep learning, to help build industry-leading technology with Large Language Models (LLMs) and multimodal systems.Key...


  • Boston, United States Tbwa ChiatDay Inc Full time

    Principal Associate Scientist, LNP DiscoveryCompany Overview:Strand Therapeutics is a clinical stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies to patients.Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological...

  • Principal Scientist

    2 weeks ago


    Boston, United States Tbwa ChiatDay Inc Full time

    Location: This position may be performed remotely with travel to the Boston area as needed.The OpportunityWe’re seeking a Principal Scientist of Process Chemistry to lead drug substance activities for one or more projects within Praxis’ portfolio to support clinical and commercial supply. Apply your knowledge to design products & processes to support...

  • Principal Scientist

    3 weeks ago


    Boston, United States Tbwa ChiatDay Inc Full time

    Location: This position may be performed remotely with travel to the Boston area as needed.The OpportunityWe’re seeking a Principal Scientist of Process Chemistry to lead drug substance activities for one or more projects within Praxis’ portfolio to support clinical and commercial supply. Apply your knowledge to design products & processes to support...


  • Boston, United States Wood Mackenzie Full time

    In the middle of the energy transition, businesses and governments are faced with significant challenges. But the pace and scale of change mean every decision is made under mounting pressure. Now, more than ever, companies need reliable data, analytics and actionable insight. Wood Mackenzie is the leading global provider of data and analytics solutions for...


  • Boston, United States Merck Full time

    Job Description Principal Scientist, Group Lead, Discovery OncologyJob Description: Our Company is currently seeking an exceptional Cancer Biologist to join Discovery Oncology located at our Longwood site in Boston, MA. The successful candidate will play a pivotal leadership role in driving high priority Discovery Oncology programs. We are looking for a...

  • Research Scientist

    7 months ago


    Boston, United States Massachusetts General Hospital Full time

    Research Scientist-(3292171) Description GENERAL SUMMARY/ OVERVIEW STATEMENT The Diabetes in Pregnancy Research Program seeks an enthusiastic Research Scientist to join our research team and advance our mission to “.” The Research Scientist, in collaboration with a multidisciplinary team, will play an instrumental role in bringing scientific...


  • Boston, United States Strand Therapeutics Full time

    Company Overview: Strand Therapeutics is a clinical stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies to patients. Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological engineers working together at MIT who were...


  • Boston, United States Tbwa ChiatDay Inc Full time

    Principal Scientist, Formulation Development (Hybrid/Boston)About Apogee TherapeuticsFounded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. We are a biotechnology company seeking to develop differentiated biologics for the treatment of...


  • Boston, United States Merck Sharp & Dohme Full time

    Job Description Principal Scientist, Group Lead, Discovery Oncology Job Description: Our Company is currently seeking an exceptional Cancer Biologist to join Discovery Oncology located at our Longwood site in Boston, MA. The successful candidate will play a pivotal leadership role in driving high priority Discovery Oncology programs. We are looking for a...


  • Boston, United States Society of Exploration Geophysicists Full time

    Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...


  • Boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...

  • Lead Data Scientist

    5 months ago


    Boston, United States The Tyche Project Full time

    Company Description We are a uniquely designed talent agency focusing on the technology sector in the Boston, MA area. Our solution is built for engineers tired of the traditional recruiting experience looking for an Agent to represent them in their current search and/or throughout their career. They search keywords.  We know key people. Job Description ...


  • Boston, United States Vertex Pharmaceuticals Full time

    Job Description General Summary: Vertex is seeking a talented individual to join our Analytical Development Department in Boston, MA. We are looking for a candidate with a strong technical background and experience in physiochemical/biophysical characterization of peptides, oligonucleotides, and small molecule drug substances and associated...


  • Boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...


  • Boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...