Principal Scientist
18 hours ago
Bonum Therapeutics, Inc. is an early-stage biopharmaceutical company creating a new class of immuno-oncology protein therapeutics that are delivered systemically but activated locally.
We are seeking an experienced and innovative Principal Scientist to join the Antibody Discovery group. The successful candidate will lead yeast surface display efforts to generate novel therapeutic molecules to advance Bonum’s biologics pipeline. The ideal candidate will be responsible for antibody discovery and engineering using antibody yeast display technologies, including library design, phage-to-yeast approaches, and sequence analysis to identify antibodies against diverse targets. The ability to work in a fast-paced and collaborative environment is critical.
Our labs are located near the bustling biotech area of South Lake Union in Seattle. We offer competitive salaries, generous equity participation, and excellent benefits.
Responsibilities:- Lead yeast surface display efforts for novel antibody discovery and antibody optimization including library design, antibody selection, and sequence analysis of output populations.
- Lead a small team as well as work in a hands-on lab-based position.
- Design creative and quantitative antibody selection approaches to identify functional antibodies against diverse targets.
- In an integrated team environment, collaborate across multiple functional areas (e.g. assay and screening, protein sciences, and phage display groups) to generate panels of lead antibody molecules to advance a pipeline of therapeutic programs.
- Stay up to date with current literature to maintain best practices and drive advancement of antibody display technologies.
- PhD in a relevant scientific discipline with 8+ years of experience, or master’s degree with 12+ years of experience. Industry experience is preferred.
- Deep expertise and hands-on experience using yeast display platforms for novel antibody discovery and antibody optimization, including experience with library design and phage-to-yeast approaches, FACS-based selection, and sequence analysis to identify antibodies against diverse targets with appropriate functionality.
- Expertise in molecular biology.
- Ability to multi-task in a fast-paced and dynamic environment.
- Ability to work collaboratively in cross-functional groups as a team player.
- Creative and quantitative problem-solving skills.
- Experience with electronic notebooks and scientific databases and applications for data management and data analysis.
- Strong technical knowledge of NGS technology including NGS library generation, QC, sequencing, and sequence analysis.
- Antibody and protein engineering experience.
- Experience with approaches for antibody epitope and paratope mapping and familiarity with protein structure analysis software.
- Experience with automation.
- Familiarity with additional methods for in vitro and in vivo antibody discovery.
- Industry experience with biologics discovery and lead selection.
The annual salary range for the position is $160k - $190k. Job level and compensation will depend on candidate qualifications. At Bonum we believe in building a diverse team of highly qualified individuals. Compensation is based on skills, experience, responsibilities and external salary benchmarks.
Benefits:- Medical, Dental, Vision, Rx (premiums fully paid for employees and covered dependents)
- Funded HSA
- 401(k) with company match
- Life insurance, short-term & long-term disability insurance
- Generous PTO and paid holidays
- Wellness Resources
- Generous equity (new hire and ongoing stock option grants)
- Training & development opportunities
- Commuter benefit (ORCA Passport), parking
-
Seattle, Washington, United States Amazon Full timeUnlock the Power of Content UnderstandingAt Amazon, we're pushing the boundaries of content understanding to deliver exceptional customer experiences. As a Principal Scientist in our Content Understanding team, you'll lead the end-to-end research and deployment of multi-modal models applied to various downstream applications.About the Role
-
Principal Scientist, Potency and Impurities
4 weeks ago
Seattle, United States Evotec WD Full timePrincipal Scientist, Potency and Impurities Principal Scientist, Potency and Impurities Just- Evotec Biologics is seeking a motivated and creative Principal Scientist who desires a significant opportunity to improve worldwide access to biotherapeutics. The candidate will join a fast-paced, collaborative, and multidisciplinary team to develop and execute...
-
Principal Applied Scientist, SP Insights
4 weeks ago
Seattle, United States Amazon.com Services LLC Full timeJob Title: Principal Applied ScientistMinimum Qualifications:MS degree (or equivalent) in Electrical Engineering, Computer Science, Mathematics, or related technical field5+ years of industrial/academic product experience, such as formal verification, program analysis, constraint-solving, and theorem proving5+ years of technical management experience5+ years...
-
Principal Applied Scientist, AGI Data Services
4 weeks ago
Seattle, United States Amazon Full timePrincipal Applied Scientist, AGI Data ServicesJob ID: 2815583 | Amazon.com Services LLCThe Artificial General Intelligence Data Service (AGI-DS) team is seeking a dedicated, skilled, and innovative Principal Applied Scientist with a robust background in deep learning, to build industry-leading technology with Large Language Models (LLMs) and multimodal...
-
Seattle, United States Amazon Full timePrincipal Applied Scientist, Amazon Private BrandsJob ID: 2835385 | Amazon.com Services LLCThe Amazon Private Brands’ Discovery team develops innovative machine learning solutions to enhance customer awareness of Amazon's private brands and help customers discover products they love. This interdisciplinary team of scientists and engineers incubates and...
-
Principal Scientist
2 weeks ago
Seattle, United States Bonum Therapeutics Full timeBonum Therapeutics, Inc. is an early-stage biopharmaceutical company creating a new class of immuno-oncology protein therapeutics that are delivered systemically but activated locally.We are seeking a principal scientist to join our growing team. As part of a well-supported and integrated group, the successful candidate will help drive our strategy to create...
-
Principal Data Scientist, Prime Video
3 weeks ago
Seattle, United States Amazon Full timePrincipal Data Scientist, Prime Video - Discovery ScienceJob ID: 2662708 | Amazon.com Services LLCAre you interested in shaping the future of entertainment? Prime Video's mission is to be the #1 entertainment destination for customers worldwide and Prime Video’s technology teams are creating best-in-class digital video experience.As a Prime Video...
-
Principal Applied Scientist, APM Stores
1 day ago
Seattle, United States Amazon Full timeJob ID: 2836065 | Amazon.com Services LLCOur team drives innovation for the onsite retail shopping site publisher. We collaborate and influence the advertising science community at Amazon across the entire Ads stack— sourcing and ranking ads, bidding into and pricing in the ads auction, experimentation design to measure causal impact of showing ads on...
-
Principal Applied Scientist, Amazon Prime
4 days ago
Seattle, United States Amazon Full timeJob ID: 2846094 | Amazon.com Services LLCAmazon Prime’s Science organization leads the Research & Development towards innovation for Amazon Prime. Amazon Prime is the backbone of Amazon’s consumer business and aspires to be the world’s most engaging, satisfying, and loved membership program, driving growth and profitability. The program serves over 200...
-
Seattle, United States Amazon Full timePrincipal Research Scientist, AWS Industry ProductsJob ID: 2820652 | Amazon Web Services, Inc.AWS Industry Products (IP) is a new AWS engineering organization chartered to build new AWS products by applying Amazon’s innovation mechanisms along with AWS digital technologies to transform the world, industry by industry. We dive deep with leaders and...
-
Principal Scientist
4 days ago
Seattle, United States Evotec WD Full timePrincipal Scientist - Seattle, WAJust is seeking a highly motivated Principal Scientist who desires a significant opportunity to improve worldwide access to biotherapeutics. The candidate will join a fast-paced, collaborative, and multi-disciplinary team focused on developing and advancing biotherapeutics from discovery to First-in-Human. The successful...
-
Principal Research Scientist
4 weeks ago
Seattle, United States Amazon Full timePrincipal Research Scientist , Amazon SearchJob ID: 2698252 | Amazon.com Services LLCAre you passionate about delighting hundreds of millions of customers and building the best search experience to help customers make well-informed purchase decisions on Amazon? Are you passionate about building the next generation product shopping and search experience? The...
-
Principal Applied Scientist
1 week ago
Seattle, United States Amazon Full timePrincipal Applied Scientist - CV/ML, Amazon RoboticsJob ID: 2843016 | Amazon.com Services LLCDo you want to create worldwide impact in robotics while solving challenges at the edge of robotics research? Our team in Amazon Robotics builds high-performance, real-time robotic systems that can perceive, learn, and act intelligently alongside humans—at Amazon...
-
Seattle, United States Amazon Full timeJob ID: 2846094 | Amazon.com Services LLCAmazon Prime’s Science organization leads the Research & Development towards innovation for Amazon Prime. Amazon Prime is the backbone of Amazon’s consumer business and aspires to be the world’s most engaging, satisfying, and loved membership program, driving growth and profitability. The program serves over 200...
-
Principal Scientist, Potency and Impurities
2 days ago
Seattle, WA, United States Evotec WD Full timePrincipal Scientist, Potency and Impurities Principal Scientist, Potency and Impurities Just- Evotec Biologics is seeking a motivated and creative Principal Scientist who desires a significant opportunity to improve worldwide access to biotherapeutics. The candidate will join a fast-paced, collaborative, and multidisciplinary team to develop and execute...
-
Seattle, WA, United States Amazon Full timePrincipal Applied Scientist, AGI Foundations Job ID: 2762609 | Amazon.com Services LLC As a Principal Scientist within the Artificial General Intelligence (AGI) organization, you are a trusted part of the technical leadership. You bring business and industry context to science and technology decisions.You set the standard for scientific excellence and make...
-
Principal Applied Scientist
1 week ago
Seattle, United States Amazon Full timePrincipal Applied Scientist - CV/ML, Amazon RoboticsJob ID: 2843016 | Amazon.com Services LLCDo you want to create worldwide impact in robotics while solving challenges at the edge of robotics research? Our team in Amazon Robotics builds high-performance, real-time robotic systems that can perceive, learn, and act intelligently alongside humans—at Amazon...
-
Seattle, United States Amazon.com Services LLC Full timeAt Prime Video we are inventing a customer-centric future that offers more choice and flexibility than traditional Cable, Satellite television and other streaming providers. Where you can watch video content such as Prime Originals (Fallout, The Boys, The Marvelous Mrs. Maisel), movies, TV shows, Live sports (Thursday Night Football, English Premier League),...
-
Seattle, WA, United States Amazon Full timePrincipal Applied Scientist, AGI Data Services Job ID: 2815583 | Amazon.com Services LLC The Artificial General Intelligence Data Service (AGI-DS) team is seeking a dedicated, skilled, and innovative Principal Applied Scientist with a robust background in deep learning, to build industry-leading technology with Large Language Models (LLMs) and multimodal...
-
Seattle, WA, United States Amazon Full timePrincipal Applied Scientist, Amazon Private Brands Job ID: 2835385 | Amazon.com Services LLC The Amazon Private Brands’ Discovery team develops innovative machine learning solutions to enhance customer awareness of Amazon's private brands and help customers discover products they love. This interdisciplinary team of scientists and engineers incubates and...
