Assoc. Principal/Principal Bioinformatics Data Scientist
2 months ago
Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and advance breakthrough therapies for the toughest diseases.
We are seeking an exceptional (Associate) Principal Bioinformatics Data Scientist with a strong background in computational biology and human genetics to drive the further development and application of multi-omics methods core to our cutting-edge drug discovery platform. In this role, you will be working hand-in-hand with bench scientists to translate complex research questions into insightful experiments and analyses and leading the design and execution of bioinformatics workflows that make sense of rich ‘omics data.
You’ll be an integral part of a collaborative, cross-functional Data Science and Engineering team, employing diverse methods that span the full R&D process and leverage various data modalities, from imaging and chemical structure to medical records and multi-omics. Key to success in this role is deep expertise in statistical methods for ‘omics data analysis—particularly RNAseq and WGS—combined with the ability to distill complex findings into impactful insights for our biology and chemistry teams.
Dewpoint offers competitive salary, great benefits, and amazing perks. You’ll be part of a purpose-driven and supportive startup culture, engaged in continuous learning, and part of an exceptional international team. This role is based at our site in the Seaport area in Boston (though can be hybrid) and reports to the Head of Data Science and Engineering.
In this role, the key responsibilities will be...
- Working with bench science colleagues to translate research questions into appropriate experiments and bioinformatics analyses
- Designing and implementing new computational approaches to analyze ‘omics data in ways that address novel questions and challenges arising in our drug discovery research
- Running and refining bioinformatics workflows and pipelines for the analysis of ‘omics data, particularly RNAseq and WGS data
- Integrating other datasets, such as pathway / network databases, to derive biological insights and get to ‘so what’ results
- Synthesizing and communicating results effectively to colleagues, and iteratively refining methods based on their feedback
- Owning delivery of bioinformatics workstreams end-to-end, potentially including the mentoring and coaching of junior colleagues
- Continually learning and growing as a bioinformatician, identifying emerging methods and tools to implement where appropriate
- Contributing to developing bioinformatics and data science understanding, capabilities, and standards across the organization
To do this, you will need…
- A PhD in a relevant computational field such as Bioinformatics, Computational Biology, Genomics, or a related discipline
- 4+ years of industry experience (in pharma or biotech) post-PhD in computational roles, with demonstrated impact
- Proficiency in R and/or Python, with a high level of comfort in data manipulation and analysis
- Hands-on research experience in transcriptomics and genomics, with additional experience in proteomics and ChIP-seq data preferred
- Expertise in statistical methods for ‘omics data analysis, particularly for RNAseq (e.g., DGE, GSEA, GSVA) and WGS data (e.g., GWAS, PheWAS, e-/p-QTL, variant burden testing), including quality control methods
- Experience integrating ‘omics data with pathway/network datasets to draw biologically meaningful insights
- Solid understanding of molecular biology principles, ideally within a research or drug discovery setting, with a strong grasp of oncology fundamentals
- Outcome-driven approach with the ability to explore alternative methods pragmatically while prioritizing high-impact solutions
- Proven analytical and problem-solving abilities, with a track record of innovative solutions
- Collaborative and communicative style, adept at working with colleagues across varying levels of expertise and seniority
It would be nice but not required to have…
- Experience working in the cloud (AWS) and with code management tools (Git) in collaborative team environments, including with containers and workflow orchestration tools such as Nextflow
- Experience with relevant public datasets, such as TCGA, depmap, UK Biobank etc.
- Experience training and working with machine learning models
- Experience working with knowledge graphs
About Dewpoint
Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Dewpoint scientists are working in Boston, MA, and Dresden and Berlin, Germany, to translate condensate biology into treatments for the toughest diseases.
Dewpoint Therapeutics is an equal opportunity employer committed to the principles of non-discrimination in the workplace. Candidates will not be discriminated against based on age, race, creed, color, religion, sex, sexual orientation, national origin, disability, marital status, or any other basis prohibited by federal, state, or local law.
Dewpoint Therapeutics has an anti-hate policy in place, along with an active staff-led Diversity, Equity, and Inclusion Committee sponsored by the CEO.
Please, no solicitations by agencies.
-
Boston, United States Society of Exploration Geophysicists Full timeDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...
-
Boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...
-
Boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...
-
Boston, United States Dewpoint Therapeutics Full timeDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging this transformation in understanding of cellular biology to discover and...
-
Principal Data Scientist
3 weeks ago
Boston, United States Wood Mackenzie Full timeIn the middle of the energy transition, businesses and governments are faced with significant challenges. But the pace and scale of change mean every decision is made under mounting pressure. Now, more than ever, companies need reliable data, analytics and actionable insight. Wood Mackenzie is the leading global provider of data and analytics solutions for...
-
Principal Applied Scientist, AGI Automations
2 weeks ago
Boston, United States Amazon Full timePrincipal Applied Scientist, AGI AutomationsJob ID: 2849765 | Amazon.com Services LLCThe Artificial General Intelligence (AGI) team is looking for a passionate, talented, and innovative principal applied scientist with a strong background in deep learning, to help build industry-leading technology with Large Language Models (LLMs) and multimodal systems.Key...
-
Principal Applied Scientist, AGI Automations
2 weeks ago
Boston, United States Amazon Full timePrincipal Applied Scientist, AGI AutomationsJob ID: 2849765 | Amazon.com Services LLCThe Artificial General Intelligence (AGI) team is looking for a passionate, talented, and innovative principal applied scientist with a strong background in deep learning, to help build industry-leading technology with Large Language Models (LLMs) and multimodal systems.Key...
-
AI Principal Data Scientist
1 month ago
Boston, United States Wood Mackenzie Full timeIn the middle of the energy transition, businesses and governments are faced with significant challenges. But the pace and scale of change mean every decision is made under mounting pressure. Now, more than ever, companies need reliable data, analytics and actionable insight. Wood Mackenzie is the leading global provider of data and analytics solutions for...
-
Senior Bioinformatics Scientist
3 weeks ago
Boston, MA, United States Boston Children's Hospital Full timeAt Boston Children's Hospital, the quality of our care - and our inclusive hospital working environment - lies in the diversity of our people. With patients from local communities and 160 countries around the world, we're committed to reflecting the spectrum of their cultures, while opening doors of opportunity for our team. Here, different talents pursue...
-
Principal Scientist, Formulation Development
1 month ago
Boston, United States Tbwa ChiatDay Inc Full timePrincipal Scientist, Formulation Development (Hybrid/Boston)About Apogee TherapeuticsFounded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. We are a biotechnology company seeking to develop differentiated biologics for the treatment of...
-
Boston, United States ProFound Full timeCompany Summary: ProFound Therapeutics is discovering proteins hidden within the expanded human proteome to uncover novel drugs and drug targets, producing first-in-class medicines for a multitude of diseases. The company's ProFoundry Platform uses state-of-the-art protein detection technologies to systematically identify and validate proteins and dissect...
-
Principal Scientist
4 weeks ago
Boston, United States Tbwa ChiatDay Inc Full timeLocation: This position may be performed remotely with travel to the Boston area as needed.The OpportunityWe’re seeking a Principal Scientist of Process Chemistry to lead drug substance activities for one or more projects within Praxis’ portfolio to support clinical and commercial supply. Apply your knowledge to design products & processes to support...
-
Principal Scientist
4 weeks ago
Boston, United States Tbwa ChiatDay Inc Full timeLocation: This position may be performed remotely with travel to the Boston area as needed.The OpportunityWe’re seeking a Principal Scientist of Process Chemistry to lead drug substance activities for one or more projects within Praxis’ portfolio to support clinical and commercial supply. Apply your knowledge to design products & processes to support...
-
Boston, United States Atlas Venture Full timePrincipal Scientist/Sr. Principal Scientist, Chemical Development (Must Have Small Molecule Experience)Company Address: 1 Winthrop Square, Suite 400, Boston, MA, 02110About Scorpion TherapeuticsScorpion Therapeutics was founded to expand the reach of precision medicine to more people with cancer. The company is integrating cutting-edge technologies across...
-
Principal Scientist, Gene Editing
3 weeks ago
Boston, United States Ensoma Full timeOpen Position: Principal Scientist, Gene EditingLocation: Boston, MAJob Id: R101# of Openings: 1We are seeking a highly motivated and skilled Associate Director to join our Gene Editing team to develop innovative CRISPR-based therapeutics for treating diseases. You will work with colleagues from the protein engineering, biology, and early translation teams...
-
Senior/Principal Software Engineer
1 week ago
Boston, United States Precede Full timeAbout Us Founded in 2021, Precede Biosciences is a diagnostic company pioneering a minimally invasive, comprehensive epigenomics platform. Our technology has the potential to profoundly impact the research and development of new medicines and getting the right therapy to the right patient at the right time. More information on our company and platform can be...
-
Senior/Principal Software Engineer
1 week ago
Boston, United States Precede Full timeAbout UsFounded in 2021, Precede Biosciences is a diagnostic company pioneering a minimally invasive, comprehensive epigenomics platform. Our technology has the potential to profoundly impact the research and development of new medicines and getting the right therapy to the right patient at the right time. More information on our company and platform can be...
-
Principle Data Scientist
3 weeks ago
Boston, United States ZipRecruiter Full timePrincipal Data Scientist Position (REMOTE) About Us: Our client is at the forefront of revolutionizing healthcare by empowering physicians to return to the heart of patient care. Our organization is built on the expertise of leading physicians, public health experts from prestigious institutions, cutting-edge technologists, and pioneers in healthcare...
-
Senior Bioinformatics Specialist
2 weeks ago
Boston, Massachusetts, United States Rancho BioSciences LLC Full timeJob SummaryRancho Biosciences LLC is seeking a senior-level bioinformatics specialist to provide analytical services in various client-facing tasks. This role will be focused on leading and expanding our impact in the analysis of inherited and somatic sequence variation.This includes individual contributions to computational biology projects, as well as...
-
Senior Manager NGS Bioinformatics
3 weeks ago
Boston, United States Mass General Brigham (Enterprise Services) Full timeDescriptionThe OpportunityI. Leadership and Management:Lead and manage a team of bioinformaticians, providing mentorship and guidance.Works with senior leadership to establish goals and objectives including the definition of work products and timelines. May also participate in developing strategy and setting overall direction.Develop and implement strategic...
