Molecular Biologist

Seeking a Molecular Biologist to join a growing Biotech company in the Spring House, PA area.

Key Responsibilities:

The primary responsibilities of this position include, but are not limited to:

• Work independently and as part of an interdisciplinary team to support the development and evaluation of non-viral gene therapies using the company’s novel DNA scaffold technology.
• Molecular characterization of biomolecules including DNA-conjugated modalities including peptides, antibodies, proteins, and small molecules.
• Test various molecules and modalities for biochemical suitability, potential efficacy and safety using cell-based assays combined with various analytical methods.
• Develop cell and molecular assays to assess cell fate, potency and durability of the delivery scaffold and genetic payloads.
• Design and test cell-based protocols for transfer to the Development team.
• Maintain data acquisition and analysis in electronic laboratory notebook.

Basic Qualifications:

• BS degree in Cell Biology, Molecular Biology, Biochemistry, Pharmaceutical Sciences with 2-5 years or a MS degree with 0-2 years of research and development experience.
• Experience with mammalian cell culture and knowledge on cell based assays.
• Detail-oriented with strong organizational and communication skills.
• Experience with DNA and RNA extraction methods and downstream use.
• Hands-on experience with standard laboratory equipment and procedures.
• Able to digest complex articles and reviews and pull relevant information, ideas, and methodologies for experimental use.
• General understanding of cell-based assays and outcomes.
• Knowledge of peptide and protein structure and function.
• Basic analytical characterization methods.

Preferred Skills/Experience:

• Experience with flow cytometry cell-based assays for quantitative assessment of results.
• Experience with qPCR, ddPCR and other qualitative and quantitative nucleic acid analysis methodologies.
• Experience in performing plate and bead-based pulldown and analytical assays.
• Able to troubleshoot experiments and instrument issues.

Only local candidates will be considered.