Work In Biotech | Research Assistant, Medicinal Chemistry

4 days ago

san diego, United States Work In Biotech Full time

Our client, Architect Therapeutics, was recently founded to explore completely new, highly coveted chemical space for addressing challenging molecular targets (expand the “druggable universe”) using a combination of leading-edge C-H activation technologies (from Prof. Jin-Quan Yu laboratory) and activity-based-protein-profiling (from Prof. Ben Cravatt laboratory).


We are looking for an undergraduate or BS level chemist pursuing their Master’s degree to perform library (array) synthesis and purification for small molecule drug discovery projects. The successful candidate will further develop synthetic chemistry skills. They will be trained on automated parallel synthetic chemistry and analytical chemistry techniques and will have the opportunity to learn medicinal chemistry serving as a member of our drug discovery project team.


This position is for a 12-month period from January-December 2025; ideal for an active student. This is an onsite position requiring a minimum 10 hr/week commitment.


Key Responsibilities:

  • Learn to use library synthesis equipment and reverse phase HPLC to perform library synthesis and purification
  • Prepare small molecule libraries and characterize and evaluate product purity by LCMS
  • Optimize the process for library production by increasing reaction success rates and reducing cycle times
  • Document all experiments performed in electronic notebook, including data analysis and QC
  • Present findings to supervisor and project team on regular basis


Qualifications and Experience:

  • BS or MS with previous lab experience, experience in industry is a plus
  • Completed or enrolled in coursework in organic chemistry. Must have completed two years of laboratory chemistry courses. Previous summer research experience in organic chemistry preferred.
  • Highly motivated, productive, and goal-driven with hands-on laboratory experience including synthetic chemistry and purification techniques
  • Have familiarity with reading scientific literature and able to apply to experimental design
  • Have high attention to detail to promote reliable and reproducible data generation, strong recordkeeping skills, and ability to communicate within a laboratory environment
  • Strong experience with basic Microsoft Suite (Excel, PowerPoint, Word, Outlook) and chemistry software (ChemDraw).
  • Familiarity with lab automation and/or high throughput instrumentation is a plus

  • Research Assistant, Medicinal Chemistry

    4 days ago

    San Diego, United States Work In Biotech Full time

    Our client, Architect Therapeutics, was recently founded to explore completely new, highly coveted chemical space for addressing challenging molecular targets (expand the “druggable universe”) using a combination of leading-edge C-H activation technologies (from Prof. Jin-Quan Yu laboratory) and activity-based-protein-profiling (from Prof. Ben Cravatt...

  • Work In Biotech | Research Assistant, Chemical Biology | san diego, ca

    4 days ago

    san diego, United States Work In Biotech Full time

    Our client, Architect Therapeutics, was recently founded to explore completely new, highly coveted chemical space for addressing challenging molecular targets (expand the “druggable universe”) using a combination of leading-edge C-H activation technologies (from Prof. Jin-Quan Yu laboratory) and activity-based-protein-profiling (from Prof. Ben Cravatt...

  • Research Assistant, Chemical Biology

    4 days ago

    San Diego, United States Work In Biotech Full time

    Our client, Architect Therapeutics, was recently founded to explore completely new, highly coveted chemical space for addressing challenging molecular targets (expand the “druggable universe”) using a combination of leading-edge C-H activation technologies (from Prof. Jin-Quan Yu laboratory) and activity-based-protein-profiling (from Prof. Ben Cravatt...

  • Senior Medicinal Chemistry Expert

    6 days ago

    San Diego, California, United States Vertex Pharmaceuticals Full time

    Senior Medicinal Chemistry ExpertThis role offers an exciting opportunity to join Vertex Pharmaceuticals as a Senior Medicinal Chemistry Expert. The ideal candidate will have a strong background in chemistry and experience in leading cross-functional teams to deliver successful drug discovery projects.The key responsibilities of this position...

  • Research Scientist

    22 hours ago

    San Diego, CA, United States Scripps Research Translational Institute Full time

    Research Scientist / Senior Research Scientist, Peptide Chemistry Position Title : Research Scientist/Senior Scientist, Peptide Chemistry ABOUT US Calibr, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr was founded on the principle that the...

  • Senior Research Associate

    2 days ago

    San Diego, California, United States Scripps Research Full time

    About UsScripps Research is a leading biomedical institute recognized for its significant impact on innovation. Our 100-year legacy is a testament to our dedication to groundbreaking research in immunology, infectious diseases, neuroscience, heart disease, cancer, and more.Located in La Jolla, California, our institute features six research departments,...

  • Senior Medicinal Chemistry Leader

    6 days ago

    San Diego, California, United States Vertex Pharmaceuticals Incorporated Full time

    Job OverviewVertex Pharmaceuticals Incorporated is seeking a Senior Medicinal Chemistry Leader to join our team in San Diego. As a key member of our research organization, you will be responsible for leading the activities of multiple groups across project boundaries, ensuring personnel goal setting is effectively linked to corporate and department...

  • Biotech Sales Representative

    6 days ago

    San Diego, California, United States Sino Biological US Inc. Full time

    Unleash Your Sales Potential in the Biotech IndustrySino Biological US Inc. is a rapidly growing company dedicated to providing high-quality reagents and contract research services to the biotech community. We are seeking a talented Junior Account Executive to join our dynamic team and contribute to our success.About Sino Biological US Inc.We specialize in...

  • Medicinal Chemistry

    4 weeks ago

    San Diego, United States Society of Exploration Geophysicists Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...

  • Medicinal Chemistry

    1 month ago

    san diego, United States Light Horse Therapeutics Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...

  • Medicinal Chemistry

    1 month ago

    san diego, United States Light Horse Therapeutics Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...

  • Medicinal Chemistry

    1 month ago

    San Diego, United States Light Horse Therapeutics Full time

    Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading...

  • Research Scientist

    7 days ago

    San Diego, California, United States Scripps Research Full time

    Scripps Research is a nonprofit biomedical institute ranked as one of the most influential in the world for its impact on innovation. We are celebrating our legacy in biomedicine, fostering groundbreaking research that transforms human health worldwide.About UsOur history spans over 100 years, marked by seminal discoveries in immunology, infectious diseases,...

  • Senior Peptide Chemist

    6 days ago

    San Diego, California, United States Scripps Research Translational Institute Full time

    Accelerate Your Career in Peptide ChemistryScripps Research Translational Institute is a renowned institution dedicated to advancing the field of biomedical research. We are seeking an experienced and highly skilled Peanut Butter Sandwich Calculator Senior Peptide Chemist to join our dynamic team in San Diego.The ideal candidate will possess exceptional...

  • Research Scientist

    6 days ago

    San Diego, California, United States Scripps Research Full time

    About UsScripps Research is a leading nonprofit biomedical institute that has been ranked as one of the most influential in the world for its impact on innovation.We are celebrating our 100-year legacy in 2024, marking a century of seminal discoveries in immunology, infectious diseases (such as COVID-19, flu, HIV), neuroscience, heart disease, cancer, and...

  • Senior Peptide Chemist

    3 days ago

    San Diego, California, United States Scripps Research Full time

    Company OverviewScripps Research, a nonprofit translational research institute, accelerates medicines by pairing world-class biomedical research with cutting-edge drug discovery and development capabilities. Our innovative approach to advancing nonprofit biomedical research shapes a new paradigm for patients while re-investing in further groundbreaking...

  • Research Scientist

    1 week ago

    San Diego, California, United States Scripps Research Full time

    About UsScripps Research is a leading biomedical institute with a century-long legacy of innovative discoveries. Located in La Jolla, California, our institution houses six research departments, multiple Nobel laureates, and a top-ranked graduate school.We collaborate with researchers from the Scripps Research Translational Institute and Calibr to merge...

  • Patent Agent Chemistry Specialist

    1 week ago

    San Diego, California, United States Hunt Hive Talent Full time

    About Hunt Hive TalentWe connect talented professionals with career opportunities that drive success. Our clients rely on us to find exceptional candidates, and our team works tirelessly to deliver results.Opportunity OverviewA forward-thinking organization is seeking a skilled Patent Agent (Chemistry) to join their intellectual property law team in San...

  • Chemistry Research Specialist

    6 days ago

    San Francisco, California, United States University of California San Francisco Full time

    Job OverviewWe are seeking a highly skilled Chemistry Research Specialist to join our team at the University of California San Francisco. This is an exciting opportunity for individuals with expertise in chemistry, technology, and education to contribute to cutting-edge research.About the RoleThe successful candidate will be responsible for conducting...

  • Process Chemistry Leader for Small Molecule Development

    4 days ago

    South San Francisco, California, United States Frontier Medicines Full time

    About Frontier MedicinesFrontier Medicines is a biotech company that specializes in the development of innovative small molecule therapies. We are seeking an experienced leader to head our Process Chemistry department and drive the development of scalable manufacturing processes for our pipeline.