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Research Associate

4 months ago

Hayward, United States Frontage Laboratories Full time
Job DescriptionJob Description

Research Associate

Title: Research Associate

Department: ADME Department

Location: Hayward, CA (on-site)

Reports to: Group Leader – ADME Department

Classification: Full-time

About Us:

Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Position/Job Summary:

This position will support experiment design, data collection, analysis, troubleshooting, and data reporting within the ADME department. This includes gathering data on pre-clinical compound parameters using a variety of techniques, organizing and processing the data using statistical and analytical methods to reach meaningful conclusions, and reporting observations to clients and other decision-makers.

Roles & Responsibilities:

  • Report to the senior team leader.
  • Work and collaborate daily with a group of in vitro assay biologists within the ADME department.
  • Learn from and teach other group members to improve skills, increase productivity, and take part in cross-training of all ADME assays.
  • Maintain a detailed laboratory notebook.
  • Develop compound methods and collect data using LC-MS/MS and other modalities (HPLC, spectrophotometry, etc.)
  • Conduct day-to-day testing of compounds in several cell/protein-based in vitro assays or experiments in a team-oriented environment.
  • Analyze and interpret data using different software programs (Sciex Analyst, DiscoveryQuant, GraphPad prism, MS Excel, etc.)
  • Prepare reports and communicate with collaborators and clients.
  • Multitask, recognize problems, provide input to solutions, draft reports, and communicate results proficiently with clients and in lab meetings.
  • Contribute to basic lab maintenance such as preparing buffers, cleaning, ordering, stocking, and follow-up.
  • Communicate and work closely with other departments to finish collaboration projects in a timely manner.
  • Offer drug discovery screening and IND filing support for multiple client-based projects
  • Other duties as assigned

Education, Experience & Skills Required:

  • BS or MS in biology, chemistry, or related area.
  • 2-4 years of related experience in the biotech, pharma or preclinical CRO industry. Working experience with LC-MS/MS, HPLC, bioanalytical studies preferred.
  • Strong problem solving and troubleshooting skills with demonstrated ability to resolve complex situations that require a logical, analytical and methodical approach.
  • Self-motivated to multitask, initiate projects, and work both independently and in a team environment to meet deadlines
  • Excellent organization and planning skills with attention to detail.
  • Committed to customer satisfaction and focused on the importance of quality.
  • Excellent interpersonal and communication skills.
  • Hands-on exposure to general biotech laboratory equipment. A preferred candidate will have a good understanding and knowledge of laboratory tools, techniques, methods, and underlying principles. Work experience in cell-culture or in an in vitro ADME/DMPK lab preferred but not required.
  • A theoretical understanding of different ADME assays (solubility, microsomal stability, plasma and blood stability, plasma protein binding, permeability, CYP enzyme and transporter inhibition and substrate determination, etc.) preferred but not required.

Significant Safety or Working Considerations:

  • May work with potentially infectious samples of human and/or animal origin (i.e. blood, tissues, etc.).
  • May handle hazardous chemicals.

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.