Biologist

2 weeks ago

Bethesda, United States Axle Full time
Job DescriptionJob Description

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).


Overview

Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Biologist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), Vaccine Production Program (VPP).

Technical Requirements: Biologist

  • Develop downstream (purification) processes, under the supervision of a project lead scientist, for recombinant proteins, virus vaccines, and virus-like particles (VLP) that may be used as clinical candidates.
  • Work collaboratively within the purification group to design, develop and optimize chromatography and filtration step unit operations to support process development of clinical trial vaccine candidates and mAb products.
  • Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles in support of other groups or external collaborators.
  • Work to prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities.
  • Support technology transfer of processes to Lab's Pilot Plant for manufacture of clinical product through document generation and on-site support.
  • Write and review technical protocols and reports.
  • Analyze and compile data, present at various group/department meetings.
  • Coordinate with project management to ensure development milestones and study deliverables are met in a timely manner
  • Work with VPP Data Science and Automation (DSA) group to create platform data analysis/visualization packages using Tableau or equivalent software
  • Support mRNA-Lipid Nanoparticle (LNP) program by designing and executing process development studies for mRNA-lipid nanoparticle encapsulation

o Serve as SME with operation and optimization of microfluidic systems, e.g. Precision NanoSystem, Inc Ignite and Blaze, and/or Knauer NanoScaler Impingement Jet Mixers

o Perform scale down and scale-up operations to support tech transfer to manufacturing and/or troubleshooting

Specific Qualifications:

  • Bachelor's degree in Bioengineering, Chemical Engineering, Biochemistry, or a related discipline.
  • 1-2 yr experience in recombinant protein purification development for GMP clinical-phase products.
  • Demonstrated knowledge of maintaining accurate and detailed records.
  • Must be a team player who can effectively work with members from cross-functional departments.
  • Strong oral and written communication skills.
  • Familiarity with computer software including word processing and data evaluation

Benefits

  • 100% Medical, Dental & Vision premium coverage for Employees
  • Paid Time Off (Including Holidays)
  • Employee Referral Bonus
  • 401K Match
  • Tuition reimbursement and professional development opportunities
  • Flexible Spending Accounts:
    • Healthcare (FSA)
    • Parking Reimbursement Account (PRK)
    • Dependent Care Assistant Program (DCAP)
    • Transportation Reimbursement Account (TRN)

The diversity of Axle's employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact:

careers@axleinfo.com

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual's assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

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