Senior Research Associate
2 months ago
Tr1X ("Trix") is a biotechnology company focused on engineering cures for autoimmune and inflammatory diseases. The company develops cellular therapies with the potential to cure disease by inducing immune tolerance and restoring homeostasis.
Tr1X has a state-of-the-art technology platform that allows for the scalable generation of engineered living drugs to help patients suffering from debilitating diseases with high unmet medical need. More information can be found at www.tr1x.bio
Position Description:The Senior Research Associate, Discovery will work with Tr1X's Research and Development team to design and execute in vitro and in vivo studies to characterize candidate cellular therapy products to support pipeline program advancement. This role offers exposure to company leadership, prime mentoring and scientific training, and an opportunity to be a high-impact contributor to the company's mission and vision. The successful candidate will have technical expertise in the design, execution, and data analysis of immunological techniques including flow cytometry, ELISA, MSD, and similar methods.
- Perform - primary human immune cell isolation, lentiviral transductions of primary cells, cell propagation.
- Execute - assays to evaluate and characterize the function and activities of cells.
- Contribute - to experimental design and method improvement/optimization.
- Evaluate - various protocols in support of process development activities.
- Maintain - detailed and highly organized documentation of experimental procedures and data.
- Analyze - data in a timely manner and present findings at team/departmental meetings.
We are building a diverse, bold, agile, and collaborative organization where each team member works closely and communicates respectfully with each other. Tr1X leadership has high expectations for themselves and for you (and so should you): we expect the company and all its employees to be deeply focused on bringing Tr1X's therapies to patients at an accelerated pace.
Key attributes to this role include attention to detail, integrity, ability to multitask and to adjust to changing priorities, and a willingness to dig in and "get things done."
You have:- A Bachelor's degree in a relevant scientific discipline and 5+ years of experience or an MS with 2+ years of experience in immunology, cell biology or related discipline including at least 2 years working with primary human cells
- Experience with cell culture for primary human cells, preferably T cells and/or Tregs.
- Experience with T-cell characterization methods (flow cytometry (multiparametric and ICS), cell-based assays (proliferation, cytotoxicity), ELISA, multiplex cytokine assays,
purification using MACS system, etc.). - Experience in data analysis using Graphpad Prism, Excel, and flow cytometry analysis software (e.g. FlowJo).
- Great attention to detail and the ability to follow detailed protocols.
- Agile and flexible mindset yet highly organized.
- Must be able to don and wear all required Personal Protective Equipment (PPE) and to stand for long periods.
- The ability to perform and excel in a start-up environment.
- Gene editing experience.
- Experience with isolation and culture of human cells from blood and blood products.
- Experience with transduction of primary T-cells with retroviral or lentiviral vectors and/or AAV.
- Previous cell therapy experience.
- Previous experience with electronic lab notebooks (ELN).
- Legally entitled to work for any employer in the US.
In addition to a competitive compensation package with stock options, Tr1X offers comprehensive benefits for our employees and their families including medical, dental and vision insurance, 401k with generous company match and more.
At Tr1X we believe that a diverse, open, and inclusive environment and culture is key to our success. Tr1X will not be influenced in recruitment, hiring, promotion or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Tr1X will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.
Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place will not create any implied obligation.
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