POSTDOCTORAL SCHOLAR

Department Overview

Oregon Health & Science University is a nationally prominent research university and Oregon's only public academic health center. It educates health professionals and scientists and provides leading-edge patient care, community service and biomedical research.

Fellows will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders.

Function/Duties of Position

A Postdoctoral Scholar position with a bioinformatics/computational, experimental, or dual focus is available immediately in the laboratory of Dr. Brian J. O'Roak, Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU) for highly motivated individuals. Highlights of Dr. O'Roak's past research successes include: pioneering trio-based exome sequencing in simplex autism and developing new technologies for rapid and economical targeted resequencing.

We are building on this experience by forming a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders. This work has the potential to dramatically improve the lives of individuals affected with these currently untreatable disorders through early intervention and biologically based personal therapies.

Areas of interest include: genomics, single-cell genomics, modeling of neurodevelopmental disorders in stem cell (iPSC) and animal systems, massively parallel functional assays, and bioinformatics.

In particular, there is an immediate need for a fellow with next-generation sequence analysis experience to lead a project exploring the role of germline mutations and somatic mosaicism in autism and other neurodevelopmental disorders (e.g. neural tube detects), for which long-term funding currently exists. This would build on our work recently published in the AJHG (see Krupp et al. 2017).

Salary for this position aligns with the NIH Scale.

Required Qualifications

* PhD, MD or MD/PhD in neuroscience, cell/molecular biology, genetics or related field
* Strong interest in developmental neuroscience
* Demonstrated ability to work independently and learn new techniques quickly
* Candidates must be well organized, self-motivated and dependable
* Excellent communication skills with the ability to plan, document, analyze and report data

Preferred Qualifications

* Intensive training in the areas of genetics/genomics, computer science, or bioinformatics
* Expertise in microscopy, generating mouse knockouts or neuronal culture
* Previous experience analyzing -omics datasets
* Familiarity with statistics and optimal study design

Additional Details

Apply here online. Please be sure to upload a cover letter and Resume or CV.

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

---