PRINCIPAL RESEARCH SCIENTIST I, DMPK SENIOR BIOLOGICS PROJECT REPRESENTATIVE
4 weeks ago
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Job Description
The AbbVie portfolio consists of several marketed products in areas including eye care, immunology, oncology, virology, and women's health as well as a pipeline containing multiple promising new molecules being studied in hundreds of clinical trials or advancing from Discovery into Development. AbbVie is a global organization with US research sites in Boston (Cambridge and Worcester, MA), Chicago (North Chicago, IL), and the San Francisco Bay Area (South San Francisco, CA). The biologics portfolio is comprised of diverse and tailored modalities including mono- and bispecific antibodies, antibody-drug conjugates, dual variable domain antibodies, antibody fragments, and other recombinant proteins as well as cell-based therapies.
The Quantitative, Translational and ADME Sciences (QTAS) group is searching for an experienced project representative to provide biologics project support across all therapeutic areas for molecules in discovery and clinical development. The position requires close collaboration with Discovery and Development project teams, clinical pharmacology, and other stakeholders, developing and executing QTAS and PK/PD strategies necessary to facilitate the advancement of our pipeline.
The Project Representative will be based in one of AbbVie's R&D locations: North Chicago, IL; Worcester, MA; Cambridge, MA; San Francisco, CA.
Key Responsibilities:
* Serve as a QTAS representative on project teams supporting the development of novel biologics; collaborate with project team members (e.g., clinical pharmacology, protein analytics, discovery, toxicology) and groups within QTAS to generate relevant data guiding target validation, biomarker selection, and candidate selection
* Develop and drive the QTAS and PK/PD strategy for large molecule discovery, preclinical, and clinical development projects to support decisions and milestone transitions
* Effectively communicate QTAS and PK/PD strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions.
* Demonstrate thorough understanding of the PK/PD and bioanalytical aspects necessary for the selection and characterization of antibodies, including considerations for bispecific antibodies, antibody-drug conjugates, and novel modalities
* Coordinate and request PK, PK/PD, and bioanalytical studies in a timely manner and communicate protocols, timelines, needs and results back to team, ensuring optimized cycle times
* Conduct value-added PK/PD-related quantitative analyses to support project team or project strategy decision-making
* Serve as a liaison with bioanalytical groups to ensure timely reagent generation, method development and sample analysis
* Prepare QTAS sections of regulatory documents (IB, IND, BLA); provide responses to regulatory questions and ensure generation of appropriate reports
Qualifications
Qualifications
* Bachelor with extensive experience (14+ years), Masters with substantial experience (12+ years), or Doctorate (Ph.D.) with at least 6 years of experience in the pharmaceutical or biotechnology industries
* Experience independently representing QTAS on biologics project teams is required (expertise with novel modalities is preferred)
* Expertise with PK analysis of biologics and relevant data analysis software such as Phoenix/WinNonlin is required
* Familiarity with modeling software such as MATLAB/SimBiology, R, Python, or Berkeley Madonna is desired
* Understanding of biologics PK/PD modeling and analytical assays for measuring biologic molecules and biomarkers (including ligand binding and mass spectrometry assays) in preclinical study samples is desired
* Demonstrated scientific leadership including generating original scientific investigative strategies and guiding those efforts to an effective and productive outcome
* Recognized expert in his/her discipline
* Demonstrated publication or patent record; lead/senior author contributions a plus
* Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment
* Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and project driver
* High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills
* Passion for data analysis, solving technical problems and
-
North Chicago, United States AbbVie, Inc Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
North Chicago, United States AbbVie Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
North Chicago, United States BioSpace Full timeJob DetailsCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and...
-
Chicago, Illinois, United States AbbVie Full timeCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...
-
North Chicago, United States AbbVie, Inc Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
Principal Research Scientist I Chemistry
1 month ago
North Chicago, United States AbbVie Full time**Company Description** AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader, to develop and market advanced therapies that address some of the...
-
North Chicago, United States AbbVie Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
North Chicago, United States AbbVie Full timeJob DescriptionThe Analytical Development – External Programs group within Biologics ARD is responsible for early to late-stage development of programs with outsourced analytical activities. The candidate will serve as analytical lead on internal CMC teams and will work with external parties on method development, optimization, validation/transfer, and...
-
Principal Research Scientist I/II
3 weeks ago
North Chicago, United States AbbVie, Inc Full timeCompany Description AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader, to develop and market advanced therapies that address some of the...
-
Principal Research Scientist I Chemistry
6 hours ago
Chicago, Illinois, United States AbbVie Full timeCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...
-
Principal Research Scientist I
5 hours ago
Chicago, Illinois, United States AbbVie Full timeCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...
-
Principal Environmental Scientist
1 week ago
Chicago, United States Metropolitan Water Reclamation District of Greater Chicago Full timeGeneral Statement Under general direction, carries out or supervises applied research projects of varied scope in relation to wastewater treatment processes and oversees environmental monitoring activities. Essential Job Functions Essential job functions are fundamental, core functions common to positions in a classification. They are not...
-
Principal Research Scientist I
3 weeks ago
North Chicago, United States AbbVie, Inc Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
Principal Research Scientist I/II
12 hours ago
Chicago, Illinois, United States AbbVie Full timeCompany DescriptionAbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader, to develop and market advanced therapies that address some of the world's...
-
Senior Environmental Research Scientist
1 month ago
Chicago, United States Metropolitan Water Reclamation District of Greater Chicago Full timeGeneral Statement Under general direction, carries out more complex applied research projects in relation to wastewater treatment processes, individually or in conjunction with other investigators. Work is characterized by greater freedom of action than at the Environmental Research Scientist level. Essential Job Functions Essential job...
-
Principal Research Scientist I/II
12 hours ago
North Chicago, United States BioSpace Full timeJob DetailsCompany DescriptionAbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013, following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader, to develop and market advanced therapies that address some of...
-
Scientist II or Senior Scientist I, Bioinformatics
10 hours ago
Chicago, Illinois, United States AbbVie Full timeCompany DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...
-
Scientist I
23 hours ago
North Chicago, United States US Tech Solutions Full timePosition: Scientist ILocation: North Chicago IL 60064Contract: 6 months with possible extensionWhat are the top 3-5 skills, experience or education required for this position: 1. Knowledge of protein precipitation, liquid/liquid extraction, and solid phase extraction 2. Ability to operate and troubleshoot Hamilton Robots, Tissue Homogenizers and other...
-
Principal Research Scientist I
16 hours ago
North Chicago, United States AbbVie Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
Senior Scientist
1 week ago
Chicago, Illinois, United States Illinois Institute of Technology Full timeGeneral Description: The Institute for Food Safety and Health (IFSH) is a unique and one-of-a-kind consortium between Illinois Tech, FDA's Center for Food Safety and Applied Nutrition (CFSAN), and the food industry. IFSH comprises Illinois Tech scientists, faculty and staff, working collaboratively with FDA scientists of CFSAN's Division of Food Processing...
