Lab Associate Scientist

4 weeks ago

Irvine, United States 燃石医学 Burning Rock Biotech Full time

Key Responsibilities:

 Execute and monitor regular maintenance of laboratory equipment.

 Draft and review operational documentation.

 Ensure laboratory activities are performed in compliance with procedures and safety guidelines when handling, storing and disposing of hazardous or bio-hazardous materials.

 Prepare or produce general consumables and reagents for R&D laboratory operation.

 Prepare and handle biological specimens including blood, plasma, formalin-fixed paraffin-embedded samples, and extracted nucleic acids.

 Execute development, verification, and validation studies for novel diagnostic NGS assays.

 Process and manage samples using automated workflows and Laboratory Information Management System (LIMS).

 Author detailed, accurate, and accessible records of experimental data, present results at group meetings, to external collaborators, and preparation of reports for submission to regulatory agencies (FDA).

 Analyze and compile data for preparation of study reports and generate study reports.

 Prepare and document design control documentation, CDx assay requirements, functional specifications, performance and study results, and other data in a QSR-compliant manner.

 Partner collaboratively with the Quality Assurance and Regulatory teams to ensure that all procedural and submission documentation meets audit and accreditation standards.

 Support the timely processing and reporting of oncology samples to internal and external collaborators.

 Conduct investigations and analyses to troubleshoot and improving assay capabilities, enhance technical robustness and existing methods.

 Maintain adequate stock and efficient use of supplies necessary for performing all procedures and preparation of reagents.

 Maintain proper documentation including proper specimen handling, labeling, and quality control measures.

 Be responsible for accurately recording work performed per GLP, including results and methodology.

 Communicate with Biopharma partners and internal departments as needed to define specifics of cancer mutations and other related scientific queries.

 Utilize cancer genomics expertise to investigate genomic mechanisms of oncogenesis.

 Work collaboratively with internal colleagues to refine analysis algorithms and methods.

 Contribute scientific expertise to broader projects within the Research and Development team.

 Complete projects under guidance of senior lab employees.

 Maintain laboratory cleanliness in compliance with the Hygiene Plan.

 Perform inventory control aligned with 5S methodology.

 Perform other duties as assigned.


Qualifications:

 Bachelor’s degree in related field and 3+ years of research experience preferred in the life sciences industry; OR,

 Master’s and 2+ research experience preferred in the life sciences industry; OR,

 Familiarity with nucleic acid handling (e.g., SPRI and PCR) and quantification techniques (e.g., Nanodrop, Bioanalyzer, Fragment Analyzer, ddPCR).

 Familiarity with NGS protocols (preferred).

 Excellent organizational, communication and interpersonal skills.

 Willingness to work collaboratively in a fast paced environment with a high level of self-motivation

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