Scientist

2 days ago


South San Francisco, United States Integrated Resources, Inc ( IRI ) Full time

Title: Scientist Consultant, Antibody Discovery


Location: South San Francisco, CA


Duration: 12 months



Job Description:

  • Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display.
  • Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits.
  • Rank-order clones by affinity, in vitro potency, and early developability assessment.
  • Execute sequence optimization of lead antibodies to improve developability and binding affinity.
  • Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production.
  • Support NGS-based antibody discovery workflow.
  • Present data and updates to management and project teams.
  • Follow good documentation practice including maintaining good record keeping in Electronic Notebooks.
  • Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins.
  • Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naïve phage or yeast display library design.
  • Experience in NGS analysis for antibody discovery and engineering.
  • Significant contributions to successful biologics drug discovery programs in biotech/biopharma industry.
  • Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques.



Qualifications:

PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry).

OR

MS with 8+ years of research experience.

OR

BS with 10+ years of research experience in antibody or protein engineering.


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