Medical Research Tech III

43176BR Extended Job Title: Medical Research Tech III Org Level 1: Texas Tech Unv Hlth Sci Ctr El Paso Position Description: Employees in this classification provide support in an assigned research laboratory conducting specified phases of research projects. Performs work independently and is responsible for developing new procedures and techniques to be utilized in the laboratory and in experiments, and new applications for standard procedures and techniques. Work is performed under usual laboratory conditions. Some hazards may be present due to use of radioactive, carcinogenic or other potentially harmful substances. Responsibilities also include ensuring overall cleanliness of the laboratory and laboratory equipment, and ordering and maintaining an adequate stock of necessary supplies. May instruct or direct work of subordinate laboratory personnel. Supports translational and preclinical research projects in oncology drug discovery and therapeutic development. The lab investigates small-molecule and peptide-based modulators targeting oncogenic signaling pathways, tumor microenvironment, hormone resistance, and immune evasion. P Requisition ID: 43176BR Travel Required: None Major/Essential Functions: Conduct western blotting, ELISA, and immunoprecipitation assays to study drug–target engagement and pathwayinhibition. Perform RNA/protein isolation, qRT-PCR, cloning, mutagenesis, and transient/stable gene manipulation incancer cell lines. Culture 2D and 3D cancer spheroid models, including lentiviral/siRNA-mediated knockdowns and drug synergy studies. Conduct immunofluorescence staining and digital imaging using confocal microscopy to assess subcellular localizationand phenotypic markers. Perform live-cell imaging and apoptotic/mitotic readouts (Annexin V, TUNEL, Ki-67, H2AX, etc.). Assist in establishing xenograft, syngeneic, and orthotopic tumor models for breast, ovarian, pancreatic, and gliomastudies. Conduct drug administration (IP/SC/PO), tumor measurement, survival tracking, necropsy, tissue collection, andhistological preparation. Support pharmacokinetic/pharmacodynamic (PK/PD) sample processing and biomarkerevaluation. Maintain cell line inventory, animal colony genotyping, reagent preparation, and equipment calibration. Guide juniorlab members in standard operating procedures and contribute to manuscript and figure preparation. Uphold lab safety,IACUC, and biosafety protocols. Remains current with all licensure, certifications and mandatory compliances and trainings required of this position. Adhere to all policies, procedures and practices (Regents Rules, TTUS, HSECEP OPs, etc.). Personally demonstrate, display, and act in accordance with TTUHSCEP’s values (Service, Respect, Accountability,Integrity, Advancement and Teamwork). Actively promote and encourage staff across the institution. Performs all other duties as assigned. Grant Funded?: Yes Minimum Hire Rate: Compensation is commensurate upon the qualifications Pay Basis: Hourly Work Location: El Paso Preferred Qualifications: Laboratory experience, ideally in a translational oncology or therapeutic development setting. Proficiency in mammaliancell culture, western blotting, nucleic acid analysis, and fluorescence microscopy. Willingness and eligibility to work withmouse tumor models and BSL-2 viral vectors. Experience with targeted therapy or drug resistance models (e.g., GRantagonists, Midkine inhibitors, LIFR pathway). Familiarity with survival surgery for PDX or syngeneic tumorimplantation and IVIS/bioluminescence imaging. Skilled in scientific software (ImageJ/Fiji, GraphPad Prism, AdobeIllustrator, FlowJo). Strong organizational and data management skills with attention to reproducibility and rigor. Campus: HSC - El Paso Department: Molecular and Trans Medicine Required Attachments: Cover Letter, Resume / CV, Transcript Job Type: Full Time Pay Statement: Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as, the institutional pay plan. For additional information, please reference the institutional pay plan on the Human Resources webpage. Job Group: Research Technicians Shift: Day EEO Statement: All qualified applicants will be considered for employment without regard to sex, race, color, national origin, religion, age, disability, protected veteran status, or genetic information. Required Qualifications: Bachelor's degree in one of the sciences, or equivalent combination (4 years) of job-related experience and collegeeducation. Experience may be substituted for college education on a year for year basis. Does this position work in a research laboratory?: Yes Are select agents used in this laboratory?: Yes Jeanne Clery Act: The Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act is a federal statute requiring colleges and universities participating in federal financial aid programs to maintain and disclose campus crime statistics and security information. By October 1 of each year, institutions must publish and distribute their Annual Campus Security Policy & Crime Statistics Report (ASR) to current and prospective students and employees. You can locate this report through our website at: