Director, Computational Chemistry
4 weeks ago
- As the ASSOCIATE/DIRECTOR, COMPUTATIONAL CHEMISTRY, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Structural biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects.
- You will contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics.
- You will implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts.
Responsibilities:
- Responsible for visibility and representation of Computational Chemistry Accomplishments to the executive team.
- Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
- Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
- Provide important technical knowledge and input to project teams to drive decision making in drug discovery projects.
- Manage and mentor a Strong team of Computational Chemists to high productivity levels
Requirements:
- PhD degree in a Computational Chemistry with 10+ years experience in Pharma/Biotech
- 10+ years of Industry experience including 2+ years in leadership roles and mentoring direct reports is required
- Strong expertise in a variety of computational tools and methodologies including Docking, Virtual screening, Molecular dynamics, Free energy perturbation, Homology modeling, Quantum mechanics, Pharmacophore elucidation, Data mining, Cheminformatics, Clustering, Similarity & Diversity analysis.
- Strong Impact on progressing Discovery Projects from Hits to Clinical Leads
- Strong knowledge & experience in using a variety of tools for Hit ID
- Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.
- Contribute to the design, development and deployment of AI platforms to impact drug discovery.
- Identify and implement novel computational chemistry algorithms, technologies, and workflows.
- Strong Proficiency with state of the art Computational chemistry software.
- Proficiency in scientific scripting and programming languages
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