Principal Investigator, Translational Science

4 weeks ago

Waltham, United States Ventus Therapeutics Full time

About us:

Ventus Therapeutics is a clinical-stage biopharmaceutical company deploying leading-edge structural biology and computational chemistry tools to create novel small molecule medicines for challenging targets in immunology, inflammation, and neurology.


Our proprietary drug discovery platform, ReSOLVE, gives us the ability to discover and develop medicines through unique insights into protein targets and to create dynamic blueprints that can guide the development of differentiated therapies at a fast pace. We aim to use the ReSOLVE platform to improve the way medicines are discovered and developed, with the ultimate goal of restoring the health of people facing serious illnesses.


Position overview:

Ventus is seeking an experienced translational scientist to lead the design and execution of biomarker strategies in support of our early and late-stage research programs. The candidate will be responsible for the development of translational biomarker approaches that measure target engagement, pharmacodynamics and disease pathology. As a strategic leader within a multidisciplinary team, the candidate will ensure that biomarker strategies align with the most current understanding of inflammatory disease biology and enable early clinical proof-of-concept. The candidate is expected to take a hands-on approach in the pre-clinical validation of such approaches using disease biospecimens. This role is a unique opportunity to work at the interface of discovery and development while championing biomarker-initiatives that have a direct impact on novel clinical study design.


Responsibilities:

  • Lead efforts to develop and implement translational biomarker strategies that assess proof of mechanism, establish early signs of efficacy and enable proof of concept studies
  • Partner with preclinical scientists to design and execute translational research to validate biomarker strategies
  • Collaborate with research and clinical teams to ensure the integration of biomarker discoveries into the design of early clinical studies
  • Oversee clinical validation of biomarker assays and collaborate with clinical pharmacology in the analysis of clinical biomarker studies
  • Contribute to discovery pipeline as a biology team representative


Requirements:

  • PhD with primary focus in Immunology with at least 8 years of pharmaceutical or biotechnology industry experience
  • Experience in small molecule drug discovery and program leadership
  • Experience in the identification and validation of pharmacodynamic and disease biomarkers, as well as their clinical implementation
  • Ability to drive and influence projects from discovery through early clinical development with a focus on the identification of indications and development of biomarker strategies that enable early proof-of-concept
  • Outstanding analytical, research and organizational skills
  • Strong interpersonal, influencing, and collaboration skills
  • Ability to prioritize, and be highly productive and flexible in a fast-paced, team-oriented environment
  • Ability to communicate scientific results to diverse audiences, in a clear and concise manner

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