Sr Scientist, Proteomics

1 month ago

Chicago, Illinois, United States AbbVie Full time

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Job Description

We are seeking a mass spectrometry-based proteomics scientist to join the Chemical Biology and Mass Spectrometry Technologies team in the Technology and Therapeutic Platforms department with a focus on working with therapeutic area biologists to discover new drug targets and inform drug mechanism-of-action studies. This scientist will collaborate strongly with chemical biologists to characterize off targets. The successful candidate will have demonstrated success: 1) preparing samples from cells or tissues for expression proteomics, phosphoproteomics, and interaction proteomics experiments using either data independent acquisition or tandem mass tag approaches, 2) operating and maintaining nano-LCs and tandem mass spectrometry systems, 3) processing data with MaxQuant, Spectronaut, and DIANN, or equivalent software, and 4) utilizing R-scripting and visualization tools to empower collaborators to interpret proteomics datasets. Critical is the ability to clearly communicate their work with scientists from diverse backgrounds and design follow-up experiments for hypothesis testing to grow the drug discovery pipeline. The successful candidate will provide key contributions to advance AbbVies therapeutic area programs, contribute to the development of novel therapeutic modalities, and innovate and expand the capabilities of the proteomics platform.

Key Responsibilities:

Conceptualize, plan, and execute, all facets of a proteomics experiments to identify new drug targets or understand mechanism of action Operate and maintain nano LC equipment (various vendors) and current models of Thermo and Bruker mass spectrometers Prepare samples from cells and tissues for proteomics Propose and evaluate novel methods and technologies to prepare samples from limited amounts of cells / tissue and utilize automation to process samples in 96-well plates Interface and collaborate with colleagues and project teams in therapeutic areas to determine appropriate proteomics approaches to best address project needs. Engage in external collaborations where opportunities align with team mission. Maintain good written records of laboratory procedures and communicate research findings in cross-functional project team meetings, external conferences,andpublications. Mentor and enable the growth of team members Streamline and optimize current proteomic workflows while exploring and developing new methodologies .
Qualifications
Qualifications

Basic:

BS, MS, or PhD in chemistry, biology, biochemistry with typically BS), MS), or 0-4+ (PhD) years in industry Experience generating proteomics samples from cells and tissues for label-free and TMT-based assays Experience performing immunoprecipitations for MS interaction mapping and preparing samples for phoshphoproteomics Operate, troubleshoot and maintain nano liquid chromatography equipment and TIMS-TOF and Orbitrap mass spectrometers Ability to process data using various data processing packages such as Maxquant / Perseus, Spectronaut, DIANN, or equivalent Effective verbal and written communication skills with a strong publication and/or speaking record. High attention to detail, creativity in problem-solving, strong interpersonal skills, and ability to successfully work independently. Can-do attitude/team-oriented/open to tackling new challenges. Demonstrated success using proteomics for target identification of defining a mechanism of actionPreferred: Experience in advanced techniques such as: Proximity proteomics experiments Post translational modifications beyond phosphorylationSingle-cell proteomics Liquid handling or other lab automation systems Mentoring / teaching proteomics techniques to team members Working on a multi-disciplinary team Key Leadership Competencies: Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance. Learns fast, grasps the 'essence' and can change the course quickly where indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures, and manages innovation to reality.Position will be hired based on level of experience.

Sr Scientist I or Sr Scientist II
Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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