Biologist - Neuroscience Research

3 weeks ago

Cambridge, Massachusetts, United States Eli Lilly and Company Full time

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. #WeAreLilly

Responsibilities

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our Neuroscience Next Generation Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Are you looking to be part of a growing, driven team where you will help to progress new therapeutic approaches toward clinical development and commercialization? Oligonucleotide-based therapies and other novel modalities represent an existing avenue of research toward development of the next generation of therapies.

The Next Generation Therapeutics group is a newly formed team with a focus on using novel therapeutic modalities to deliver medicines for chronic pain and neurodegenerative disorders. The group, based at our Lilly Seaport Innovation Center, will work with internal and external partners to identify and deliver novel therapies into patients at speed. The team is seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we leverage innovative RNA/oligonucleotide/gene and genomic based therapeutic modalities to enhance our portfolio.

Key Objectives/Deliverables:

Perform histological lab techniques including, but not limited to tissues grossing, processing, paraffin embedding, tissue sectioning, routine and special tissue staining, and image analysis.Contribute to development, implementation, and execution of complex immunohistochemistry (IHC), immunofluorescence (IF), and RNAscope based assaysContribute to development, validation, and performing histological protein detection assays (including antibody evaluation and characterization) and other fit-for-purpose neuropathological assays to evaluate in vivo efficacy of therapeutic agents Assist in troubleshoot technical challenges and provide scientific/technical input to project teamsDesign, execute experiments and perform data analysisProvide conceptual input into experimental design, integrated data analysis and communication of results to scientific teams and managementProvide written and verbal communication of work in lab reports and team meetingsAccurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standardsGeneral laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipmentEnsure compliance with all health and safety regulationsReport on-site, in the lab, 5 days a weekMinimum Qualifications:Bachelor's degree in Neuroscience, biological sciences or related fieldsAdditional Skills/Preferences:Track record of delivering neuropathology-based outcomesPrevious experience in neuroscience research and/or oligonucleotide drug discovery is strongly preferredHands-on experience in tissue sectioning (including formalin fixed paraffin embedded [FFPE] and frozen tissue sectioning), immunohistochemistry, immunofluorescence, and in situ hybridization (including multiplexed formats using automated equipment [Leica]), light microscopy and fluorescence microscopy (including Aperio slide scanners)Knowledge of relevant image analysis software packages: HALO, HALO-AI, ImageScope, GraphPad Prism etc.Ability to adapt and exercise flexibility for changing platform needs, workflows and projects.Ability to craft, execute and interpret experiments independently, and to advance scientific understanding.Excellent communication skills and efficiency in collaborating across functional boundaries and in team environmentStrong organization skills, attention to detail, critical thinking, multitasking, desire to learn new techniques and contribute to cutting-edge projects in a fast-paced working environmentExcellent interpersonal skillsExperience in processing, organizing, analyzing and visualizing data and information from disparate sources and ability to extract insight from dataFamiliar with Excel, Word, PowerPoint, and analytical software associated with methods. Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups. #WeAreLilly

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