At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

At DICE Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, we design and develop innovative therapies in immunology. Our goal is to help patients with debilitating diseases. We aim to create a future where convenient oral medicines with biologic-like efficacy are available. We are developing oral alternatives to medicines currently limited to injectable forms.Responsibilities:

We are seeking an Advisor, Drug Metabolism and Pharmacokinetics. This role requires expertise in designing, conducting, and interpreting in vitro ADME and preclinical PK and PK/PD studies. These skills are crucial for advancing DICE's small molecule Discovery & Development portfolio. The successful candidate will have strong laboratory, analytical, and project management skills, along with a solid foundation in drug disposition (ADME) science.

Conduct and/or oversee conduct of in vitro permeability, protein binding and other binding studies, metabolic stability, inhibition, phenotyping, transporters, and/or other in vitro ADME studiesWork with external CROs and vendors to establish, design, perform, and interpret results from in vitro ADME and/or PK studiesContribute to optimizing workflow from compound submission to in vitro ADME and PK screening data readoutEvaluate new technologies, techniques, study designs, and/or equipment to enhance DMPK support of Discovery & Development programsUnderstand application of ADME screening data within Research programs and apply such knowledge to enhance assays and/or the design and development of novel assaysContribute to and influence the DMPK components in the screening funnel and criteria for compound selection and advancement in research programs. Identify, brainstorm, and resolve ADME/PK issues in research programs. Serve as the DMPK project representative in research programsHelp provide DMPK support to various departments such as Chemistry, Biology/Pharmacology, Toxicology, and Clinical pharmacologyResponsible for writing and/or reviewing DMPK reportsContribute to nonclinical PK/ADME sections in regulatory documents (e.g., IB, IND, etc...) Do you have experience with DMPK? Apply today to join the DICE Team Basic Requirements:PhD in a relevant scientific field with 0-5+ years of industry experienceMS in a relevant scientific field with 10+ years of industry experienceAdditional Skills/Preferences:Experience in Drug Discovery/Development DMPKStrong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skillsReasonable knowledge of PK and PK/PD studies to support characterization of small molecule therapeutics in Research programsFamiliarity with quantitative bioanalysis of plasma and other biological matrices is required. This skill supports pharmacokinetic, toxicokinetic, and in vitro ADME analyses of novel small molecule therapeuticsFamiliarity with Excel, Prism, WinNonlin Phoenix (non-compartmental PK analysis) and other relevant ADME/DMPK software Lilly currently anticipates that the base salary for this position could range from between $151,500 to $244,200 and will depend, in part, on the successful candidate's qualifications for the role, including education and experience. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Of course, the compensation described above is subject to change and could be higher or lower than the range described above. Further, Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups. #WeAreLilly

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