Investigator I

2 weeks ago


Waltham, Massachusetts, United States CSL Behring Full time
The Opportunity:

As the Investigator in Analytical Biochemistry, Vaccine Innovation Unit, you will lead assay development to support the design and optimization of the next generation of RNA vaccines and adjuvanted protein vaccines. You will focus on applying analytical and biophysical tools, such as Octet, DSC, MALS/DLS, Spectroscopy, imaging, and LC-MS etc. to characterize LNP, mRNA vaccine and adjuvanted protein vaccines. You will report to the Head of Analytical Biochemistry and service as senior member of Analytical Biochemistry group.

The Role

Develop analytical and biophysical methods to characterize lipid nanoparticles, mRNA and protein including sizing, mRNA content and encapsulation efficiency, lipid content, composition and purity, etc. Support pre-clinical studies for sa-mRNA and adjuvanted protein evaluation through vaccine fill and finish. Collaborate with Vaccine project teams, mRNA platform team and early development groups to support structure-function studies, stability studies etc. Work cross-functionally to plan and execute complex characterization studies. Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance. Maintain detailed documentation of experiments in ELN system. Operate and maintain functional laboratory equipment and follow HSE regulations. Oversee troubleshooting, tech transfer of analytical methods to downstream teams. Present scientific results internally and externally and contribute to patent application and publication. Biophysical characterization of higher-order structure using DLS, DSC etc. Review, interpret, and present data within the analytical team and cross-functionally. Author test methods, technical reports, and study protocols.Your skills and experience: PhD in Chemistry, Pharmaceutical Science, Biophysics, Biochemistry, Bioengineering, or related fields with scientific background is required. 1+ years' postdoctoral experience in academia or pharma/biotech is preferred. Experience with LNP and mRNA is highly desired. Experience with analytical techniques such as MALS/DLS, Spectroscopy, imaging, LC-MS, HPLC, fluorescence assays is highly desired. Candidates with more experience are encouraged to apply Experience with at least one or several of the analytical techniques is required: DLS, MALS, spectroscopy, imaging, mass spectrometry, HPLC (IPRP, SEC, IEX), CE. Experience with analysis of RNAs, lipids, protein and lipid nanoparticles (LNPs) is highly desirable and will be important to the success in this role. Prior experience developing analytical methods required. Knowledge/hands-on experience in oligonucleotide lipid nanoparticle delivery, production and purification of oligonucleotides, protein engineering is a plus, but not required. Benefits: Medical, Dental, Vision, Life Insurance, 401K, and PTO available from your first day of hire Our Benefits CSL Seqirus employees that work at least 30 hours per week are eligible for benefits effective day 1. We are committed to the wellbeing of our employees and their loved ones. CSL Seqirus offers resources and benefits, from health care to financial protection, so you can focus on doing work that matters. Our benefits are designed to support the needs of our employees at every stage of their life. Whether you are considering starting a family, need help paying for emergency back up care or summer camp, looking for mental health resources, planning for your financial future, or supporting your favorite charity with a matching contribution, CSL Seqirus has many benefits to help achieve your goals. Please take the time to review our benefits site to see what's available to you as a CSL Seqirus employee.About CSL Seqirus CSL Seqirus is part of CSL Limited (ASX: CSL). As one of the largest influenza vaccine providers in the world, CSL Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. Learn more about CSL Seqirus.

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