Scientist, Amplicon-seq Lead
3 weeks ago
Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just "treat" people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How You Achieve More With Intellia:
We seek a highly motivated Scientist to lead the Amp-seq team within the Genomics Innovation group. Genomics Innovation provides state-of-the-art genomics solutions, ranging from screening different editing modalities to developing and implementing a diverse toolbox of assays to characterize the impact of genome editing. The Amp-seq team is central to all research activities, and thereby critical to the development of genome editing programs and platforms. In this role, you will:
- Lead a team of junior scientists responsible for running a high throughput Illumina amplicon sequencing workflow, as well as smaller scale Pacbio amplicon sequencing workflow
- Ensure timely data delivery from amplicon sequencing workflow and work with the NGS team and automation team to promptly address run failures
- Independently and in collaboration with colleagues, apply expertise to troubleshoot and support new project needs
- Partner with the NGS assay team lead, automation, software engineering, and computational sciences teams, to optimize existing and develop new NGS workflows
- Communicate amplicon-seq process and schedule updates with submitters from diverse groups across the company
- Respond to submitter questions about sample submissions, run failures, and data quality
- Monitor, QC, and analyze data metrics, ensuring the consistent generation of high-data quality
- Serve as the NGS production assay process subject matter expert
- Work with program and platform partners to manage project queue ensuring timelines are met
- Manage and mentor junior-level scientists
- Present your or the team's work at project and larger team meetings
About You:
The successful candidate will have demonstrated expertise in Illumina NGS technology, molecular biology, and liquid handling automation
- PhD in Genomics with 0-3 years with directly relevant experience or MS with 6-9 years equivalent experience (industry experience preferred)
- Solid hands-on experience with Illumina library construction, quantification, sequencing, and data analysis. Experience with long read PacBio sequencing would be a bonus.
- Experience with running and optimizing liquid handling automation (preferably Hamilton)
- Experience with high throughput workflows and LIMS systems is preferred
- Experience with genome editing technologies (e.g. CRISPR) is preferred
- Experience in managing junior scientists is preferred
- Strong communications and documentation skills coupled with exceptional time management skills and attention to detail
#LI-KO2
Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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