Chemist

Job Description

Employee Responsibilities:
Perform routine performance checks on instruments that are being used for project support (e.g. HPLC, XRPD, moisture sorption, DSC, TGA)

Preparation of common vehicles for formulation preparation to support in vivo studies

Preparation of key reagents for analytical assays (e.g. mobile phase for HPLC)

Weighing and labelling of samples prior to shipping for studies at other sites

Solubility measurement in buffers, bio-relevant medium & organic solvents (HPLC, UV-Vis)

Vehicle Screening (e.g. solubility / stability) for SubQ, IV and PO formulation development (HPLC, UV-Vis, XRPD)

Preparation of (previously developed) formulations for animal studies including processing support for spray drying of amorphous dispersions, the preparation of particle based formulations and / or other preparation techniques as required

Forced degradation studies of drug substance (HPLC)

Preliminary physicochemical characterization of compounds / formulations including (UPLC/HPLC, XRPD, TGA, DSC, CD, FTIR, HP-SEC) and light scattering techniques (DLS, zeta potential, NTA)

Formulation analytical testing e.g. release and chemical / physical stability studies (HPLC, XRPD, UV and fluorescence assays)

Powder blending and filter analysis for inhaled programs (HPLC)

Particle size measurements of drug substance and formulations

Provide support in the maintenance of the laboratory working environment including:Cleanliness of common laboratory area

Management of waste for collection

Co-ordination of laboratory supplies (reagents / consumables)

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