Scientist I
3 days ago
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us Follow @abbvie onTwitter,Facebook,Instagram,YouTubeandLinkedIn.
Job Description
Allergan Aesthetics, an AbbVie Company is seeking a highly motivated, hands-on experimentalist for the role of Scientist I, Protein Science within the discovery research Toxin Innovation program. The successful candidate will be a key member of a protein science team, supporting the generation and production of novel biotherapeutics with improved efficacy, selectivity and developability. As part of a matrixed organization, he/she/they will have a critical role in developing and executing protein expression and purification strategies using discovery approaches and scale to select, optimize, and prioritize therapeutic protein candidates for advancement.
The Scientist I is responsible for the recombinant expression and purification of early-stage discovery proteins. The successful candidate will leverage their strong technical expertise in molecular biology and protein engineering techniques to conceive, design and execute the engineering of innovative biotherapeutics with improved efficacy, selectivity and developability. The candidate will be required to propose, design, and execute cloning strategies while demonstrating exceptional troubleshooting skills. Experience in construct design, mutagenesis, molecular cloning, Sanger Sequencing, protein expression is required.She/He/They will possess extensive expertise in E. coli protein expression, with practical knowledge of eukaryotic expression systems (baculovirus, mammalian). Demonstrated proficiency with AKTA FPLC systems developing, optimizing, and executing purification strategies (IMAC, IEX, SEC, HIC) to purify proteins with or without affinity tags is a requirement. The successful candidate will have expertise characterizing proteins (SDS-PAGE, native PAGE, ELISA, Western Blot). The candidate is expected to execute experiments with substantial independence. The candidate is expected to participate in discussions regarding the design of experiments and with guidance, have the ability to develop modified or new protocols and methods.
The position requires the candidate to productively interact with cross-functional and matrixed teams. He/She/They must be skilled in communicating and collaborating with discovery project team members at all grade levels and with diverse backgrounds, skill sets, and levels of expertise. The candidate will maintain a productive and inclusive collaborative laboratory environment consistent with department and company expectations. He/She/They must conduct all work activities in compliance with AbbVie internal and applicable regulatory requirements with strict adherence to safety policies and procedures.
Qualifications
Minimum Qualifications:
Bachelors Degree +5 or more years of experience OR a Masters degreeand 2 or moreyears of experience. Possess thorough theoretical and practical understanding of Molecular Biology, Protein Engineering, Biochemistry and/or related discipline with a focus in cloning, heterologous protein expression, protein purification and characterization.Other Required Experience:Proven experience in molecular biology and plasmid construction (PCR, site-directed mutagenesis, restriction enzyme-based cloning, ligase independent cloning (LIC)), Sanger DNA SequencingSolid knowledge in bioinformatics and sequence design/analysis software (e.g., BLAST, SnapGene, Geneious Prime)Familiarity with modeling software (Pymol) and its application to protein design.Proficient in recombinant protein expression in heterologous hosts (E. coli, baculovirus, mammalian).Skilled with AKTA FPLC purification systems.Demonstrated proficiency in protein separation techniques (IMAC, SEC, ion exchange, HIC).Experience with tagless protein purificationExperience with Molecular Biology techniques, knowledge of protein engineering strategies and protein characterization techniques including SDS-PAGE, native PAGE, ELISA and Western blot are desirableMeticulous attention to detail and diligence in record keeping.Excellent oral and written communication skills required as is experience with documentation of experimental plans, analyzing data and generating high quality technical reports.Highly autonomous and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.Understand relevant scientific literature and apply theoretical framework to solving problems within scientific discipline in a timely manner.Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this postingbased on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more orless than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. Note: No amount of payis a considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission,incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paidandmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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