Cell-intrinsic and environmental sources of mutations in cancer

4 weeks ago


New York, New York, United States NYU Langone Health Full time

Cell-intrinsic and environmental sources of mutations in cancer



The laboratory of Mia Petljak, PhD at NYU Grossman School of Medicine )

is seeking a Postdoctoral Fellow to join a multidisciplinary team investigating the cell-

intrinsic and environmental causes of somatic mutations in human tissues, as well as their

impact on cancer development and evolution. Building upon our foundational work (Cell,

2019; Nature, 2023; Nature Genetics, 2023), our team leverages mutational signatures,

distinct genomic imprints left by individual mutagens on human genomes, to identify and

characterize individual mutagenic sources. Through this approach, we aim to discover

processes that cause and fuel cancer evolution, as well as aid in the development of

innovative preventative and therapeutic strategies to prevent and treat it.



As a successful candidate, you will lead a project looking into the sources, exposure

biomarkers and/or functional impact of the suspected or poorly defined cell-intrinsic and/or

environmental mutagens in cancer. Working side-by-side with bioinformaticians, you will

benefit from learning computational aspects of the sequencing analyses, engaging in

academic and industry collaborations. Mentorship will be provided by Dr. Petljak in

translating applicable findings into patents and start-up opportunities as applicable. You will

be located with the Petljak lab in the new, state-of-the-art CURE facility at 345 Park Avenue

South in the center of Manhattan.



To apply, please submit a CV and brief statement of interests to Dr. Petljak

).

Required Education and Experience

PhD, MD/PhD, or MD.



Preference is given to applicants with strong expertise in both cell and molecular biology in

human cancer cell models. Ideal candidates will have focused expertise in the biology of

cancer cells, including but not limited to metabolism, genomic instability, DNA damage,

repair and replication, stem cells, and other cellular states and processes associated with

cancer (e.g., stress, senescence, differentiation, cell cycle, and cell death, inflammatory

signaling).



Computational experience not required.



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