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Senior Scientist 2 – Engineering Research and Development
4 months ago
You Matter to Cambrex.
Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With more than 40 years of experience and a growing team of over 2,400 professionals servicing global clients, Cambrex is a trusted partner in branded and generic markets for API and dosage form development and manufacturing.
Your Work Matters.
At Cambrex, we strive to build a culture where all colleagues have the opportunity to:
engage in work that matters to our customers and the patients they serve learn new skills and enjoy new experiences in an engaging and safe environment strengthen connections with coworkers and the community
We're committed to attracting and nurturing a passionate team of valued professionals in our fast-paced and growing company. We offer a competitive benefits package that includes medical, dental, vision, Life, LTD, retirement savings and more Can we make this broader language, so it fits in all markets, e.g., that includes healthcare, life insurance, planning for retirement, and more
Your Future Matters.
Known for our customer-focused scientific and manufacturing excellence, as well as our strong commitment to quality and safety, we offer a range of career and growth opportunities across our global network of locations. Together with our customers, we aim to improve the quality of life for patients around the world. Start a career where You Matter by applying today
Job Overview
Our Research & Development Chemical Engineer role is directed toward optimization of existing chemical routes and development of novel alternate chemistries/processes toward key synthetic intermediates and APIs. Provides CHP site engineering support, including the design, construction, and maintenance of equipment that replicates laboratory chemical process on pilot and commercial scales. Experimental skills related to chemical process development and kilo - scale synthesis of organic compounds of medicinal importance, including chemical synthesis and product isolation/purification. Utilizes analytical tools to assess product quality and process performance. Serve as an expert chemical engineering and pharmaceutical science resource to the chemical development group, the Cambrex High Point site, and to the larger Cambrex organization. Communication with clients in regular team meetings; prepares R&D and campaign reports at the conclusion of projects.
Responsibilities
Design and carry out multistep organic processes. Application of key principles of chemical engineering to work within a matrix-based chemical development team to construct systems and design chemical processes that will efficiently support on-scale safe production of promising pharmaceutical candidates. Knowledge and experience in technologies such as continuous processing and flow chemistry is preferred. Knowledge and experience with cGMP manufacturing processes is preferred. Knowledge of and experience with in-situ reaction monitoring technology is preferred. Knowledge of final form screening/polymorph screening/crystallization studies is preferred. Knowledge of process controls and associated programming is preferred. Possess a working knowledge of analytical and spectroscopic techniques, including the ability to interpret the corresponding data. Demonstrate a proficiency in laboratory and pilot-scale synthesis and purification techniques, including the implementation of process modifications. Demonstrate an ability to maintain lab equipment including pumps and instrumentation. Ability to work with minimal supervision and complete projects independently. Ability to organize work efficiently and manage time effectively. Ability to write comprehensive reports and contribute to drafting of batch records and protocols. Collaboration with process development chemists and analytical chemists to coordinate project activities as well as to develop safer and more robust processes for laboratory and plant production. Maintain current knowledge of state-of-the-art techniques for improving engineering principles related to organic chemistry, analytical chemistry, process development techniques and cGMP regulations. Knowledge of root cause/batch failure analysis. Conduct laboratory operations in a safe manner. Maintain familiarity with the company's chemical hygiene plan. Exhibit safety awareness and safe work practices. Follow responsible actions regarding chemical disposal. Maintain compliance with all regulation at the federal, state and local levels. Address routine administrative requirements in a timely fashion. Demonstrate effective communication skills. Actively promote the results of ongoing projects within the group and to external clients. Work closely with manufacturing and GMP operations to coordinate project related equipment and activities. Maintain a clean and safe lab work area.
Qualifications/Skills
Strong skills and knowledge in organic chemistry, especially as applicable to process chemistry and chemical engineering principles. Excellent verbal and written communication/interpersonal skills, problem-solving skills, organizational skills, and the ability to work in a diverse team environment are essential. Proficiency with Microsoft software (Word / EXCEL / PowerPoint) is expected. Experience with engineering software and process modeling.
Education, Experience & Licensing Requirements
PhD in Chemical Engineering or Equivalent Degree with 2 yrs experience or MS in Chemical Engineering or Equivalent Degree with 5 years experience or BS in Chemical Engineering with 8 plus years hands-on experience in the pharmaceutical or comparable chemical industry.
Cambrex is an Equal Opportunity / Affirmative Action employer and will consider all qualified applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.
Some active work, exerting up to 25 pounds of force occasionally, and/or the amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects. The daily work is performed is primarily in a laboratory setting. Walking and standing are required regularly. Position also requires visual acuity, talking and fingering. Involves regular use of basic PPE (personal protective equipment) such as supplied air respirator, negative pressure respirator, gloves, safety glasses, shielding clothing.
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