Scientist - Oligonucleotide Analysis

3 weeks ago

Indianapolis, Indiana, United States Eli Lilly and Company Full time

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.


The LIGM RNA Group is seeking an experienced analytical scientist who is both independent and self-motivated, with extensive hands-on experience in analytical techniques for characterizing and analyzing small molecules, biologics, or oligonucleotides. The ideal candidate will have a proven track record with liquid chromatography, mass spectrometry, and other advanced analytical techniques, and will bring a strong background in analytical method development and troubleshooting. We are looking for someone proficient in using state-of-the-art automation and analytical systems, including instrument control software and data visualization tools. Additionally, the candidate should demonstrate exceptional technical problem-solving skills and a proven ability to quickly learn and apply new technologies or explore new fields. The ability to work independently while delivering efficient, high-quality results in a fast-paced environment is essential.

Job Responsibilities:

Work closely with the chemistry team to source, explore, and implement the latest separation science and analytical technologies for the purification and characterization of oligonucleotides and their conjugates, including carbohydrates, lipids, peptides, and proteins.Conduct semi-preparative and preparative method development activities to advance downstream processing for challenging modified oligonucleotides, utilizing RP purification, ion-exchange chromatography, spin filtration, TFF, FPLC, size exclusion chromatography, and MS-direct auto-scale preparative LC-MS techniques.Work with the program leads in in vitro bioanalysis, as well as biophysical and biochemical characterization, to optimize sample preparation and data processing workflows using both semi-manual and automated systems.Conduct quality control activities to support early development efforts, including purity profiling, moisture content evaluation, sodium content assessment, and measurement of critical residual solvents.Work with contractors and third-party vendors to troubleshoot and maintain lab instruments, including but not limited to UPLC, LC-MS, osmometer, and NanoDrop, ensuring they remain in good operational condition.Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas.Process and present data leveraging Microsoft Office apps, GraphPad and Spotfire for data organization and data visualization.Document experiments, data, technical reports, and findings electronically in an accessible manner and good documentation practice.Present findings, progress, and data proactively and regularly in group and department meetings.Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, excellent presentation skills, and attention to detailsAbility to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks.Basic Qualifications:Bachelor's or Master's degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with 6+ years of relevant work experience.Additional Skills/Preferences:Strong analytical thinking skills with a demonstrated ability to articulate issues and extract and synthesize complex information into key focus areas.Extensive hands-on experience in downstream workflows for small molecules, biologics, and oligonucleotides.Proven expertise in analytical techniques, including liquid chromatography, mass spectrometry, and other advanced methods such as 2D-LC, SEC-MALS, CD, UV-Vis, and fluorescence spectroscopy.Prior experience in proteomics, bioanalysis, or CMC is a significant advantage.Highly self-motivated and self-driven attitude with ability to own and drive projects into success.Strong organizational and communication skills and effective people skills.Capable of continuous learning, open-minded, highly organized, and detail oriented.Ability to balance multiple activities, prioritize and handle ambiguity.
Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups. #WeAreLilly

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