Senior Research Associate

2 weeks ago

San Mateo, United States Theery Full time

Duties:

  • Work with a multidisciplinary team of automation engineers, data scientist, software developers and clinical researchers to translate results from discovery to clinical tests.
  • Working independently, and collaboratively with scientists, to perform a wide range of routine and specialized laboratory instruments and techniques.
  • Operate and maintain basic laboratory instrumentation, liquid handling automation and LCMS instrumentation.
  • In collaboration with scientists, develop and optimize novel high-throughput proteomics and metabolomics sample preparation and LCMS methods.
  • Execute biomarker discovery, verification and validation studies to further test development.
  • Communicate recent experimental results and areas for optimization to an internal multidisciplinary team.
  • Document results of analyses and investigations in a reproducible manner and communicate insights to internal team.


Requirements:

  • Bachelors or Masters degree in biochemistry or analytical chemistry with 5+ years (Bachelors) or 3+ (Masters) relevant industry experience in biological sample preparation.
  • Significant hands-on experience in biological sample preparation for proteomics, metabolomics, DMPK or genomics. Familiarity with a variety of techniques (i.e. liquid-liquid extraction, SPE, SEC, enzymatic digestion, etc.).
  • Experience in liquid handling automation maintenance and method development is desired, but not required.
  • Proven history of executing successful experiments, meeting timelines, data analysis and communication of recent results to scientific team.
  • Hands-on experience with LCMS operation, maintenance and troubleshooting
  • Experience with multiple types of LCMS system (e.g., Thermo Orbitrap, Sciex 7500, Agilent QQQ etc.) is desired.
  • Hands on experience with a variety of proteomics and metabolomics data analysis software (e.g. Skyline, Proteome Discoverer, Spectronaut, Compound Discoverer, etc.).
  • Must work well in a small team setting, with ability to work independently and collaboratively while meeting deadlines.
  • Highly organized, exceptional attention to detail and strong documentation skills.
  • Must be able to organize work, multitask and manage time effectively.
  • Excellent communications and presentation skills, as well as a desire to work across functional teams.
  • Desire to focus on breakthroughs in an exciting, fast-paced startup environment.

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