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Senior Scientist 1

2 months ago

Boston, United States Amplitude Therapeutics Full time

Company summary:


Amplitude Therapeutics is a seed-staged biotechnology company focusing on developing the next generation of RNAs to fully unlock the therapeutic potential of RNA biology. We are founded by leaders in the RNA and non-viral therapy fields and backed by premier Biotech VCs.


Position summary:

Amplitude Therapeutics is seeking a highly motivated Senior Scientist to grow our LNP formulations capability. We are looking for an individual who is passionate about being a part of a cross-functional team working to advance novel RNA medicines through delivery to common cell-types (e.g. liver, vaccine) and enable entirely new medicines by developing non-viral delivery to various high-priority cell-types including immune cells, HSCs, kidney and muscle. Responsibilities will include design, preparation, and execution of LNP formulations with field-standard lipids and novel proprietary lipids/polymers, developing and implementing various LNP analytical tools across multiple throughputs, and to interface with multiple efforts to support effective delivery for various research areas.


The ideal candidate will have 7-10 years of relevant nanoparticle experience, including 3+ years in industry working with LNPs. Comfortability with various methods of LNP formulation (e.g. PNI, T-mixer) is preferred and a track-record of productivity & independence is strongly desired. A willingness and desire to be hands-on and at the bench is required.


Key responsibilities:

  • Coordinate and execute LNP formulations of various scales to support various in vivo experiments
  • Conduct formulations of novel LNPs as part of efforts to unlock delivery of RNA to high-priority cell-types
  • Rigorously track data to link LNP physicochemical properties with in vivo performance
  • Responsible for carefully documenting research and effectively communicating results across teams.


Qualifications:

  • M.S. or Ph.D. with 8+ or 3+ years of relevant industry experience, respectfully.
  • Hands-on experience of mRNA-LNP formulation and physicochemical characterization is required
  • Familiarity with field-standard lipids (e.g. ALC-315, CL1, MC3, LP01) is a plus
  • Familiarity with LNP characterization assays (e.g. DLS, ribogreen, TNS) is required
  • Familiarity with software such as GraphPad Prism, Microsoft Office, and electronic laboratory notebooks for data analysis and data summary.
  • Highly motivated and able to be flexible in case of changing priorities.
  • Effective verbal and written communication skills.