Scientist/Senior Scientist, Functional Genomics

1 week ago


South San Francisco, United States Pattern Biosciences Full time

Scientist or Senior Scientist, Functional Genomics & In Vitro Models



Pattern Biosciences

South San Francisco, CA

www.patternbio.com


About the Company

Do you want to be at the forefront of a revolution in healthcare? At Pattern, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in individual cells, our approach leads to curative therapies where the conventional one drug-one target paradigm has failed. Pattern is building a world-class team to translate two decades of progress in DNA computing and synthetic biology into the clinic.


About the Role

Are you passionate about working with cutting-edge technologies to develop next generation therapies? You will advance the early pipeline of innovative cancer therapies harnessing our biomolecular computing platform. You will plan, build, and validate a “human in a dish” platform to ensure translational relevance of our preclinical development pipeline. You will select and establish ex vivo and in vitro models, including patient-derived samples, tumor organoids, primary cells, organs-on-chips, etc., to “debug” and fine-tune our molecular programs in a setting that is as close as possible to the patient. To do that, you will create and implement functional multi-omics workflows to profile these disease models using bulk and single cell genomics technologies. You will characterize synthetic genetic components and their combinations in the context of these models to anticipate their function in patients.


What you'll do

  • Select and establish ex vivo and in vitro models of healthy and diseased primary cells, tissues, and organs to serve as a translationally relevant testing and validation platform
  • Characterize these models using multi-modal bulk and single cell assays and approaches, such as single cell mRNA + ATAC profiling and split-pool technologies
  • Collaborate with our Synthetic Biology and Computational Biology teams to develop workflows for comprehensive high-throughput testing of multiple synthetic genetic components, their combinations, and therapeutic candidates
  • Implement multi-modal bulk and single cell assays as an integral part of testing workflows
  • Plan and manage complex projects including interfacing with clinical partners for sample acquisition and sequencing service providers
  • Liaise with CROs, plan and oversee technology transfer and study execution at contract organizations, as needed
  • Maintain detailed, well-organized documentation of experiments and data


Requirements

  • PhD in genomics, molecular biology, cancer biology, bioengineering or a related field
  • Hands-on experience performing single cell and bulk genomics experiments including sample preparation, library preparation, and sequencing
  • Excellent knowledge of ex vivo/in vitro models, ideally in cancer (tumor organoids, tumor explants), as well as healthy/primary human and animal cells (primary cells, microtissues, spheroids, organoids, organs-on-chip)
  • High motivation with a strong work ethic and dedication to generating impact
  • Ability to go from idea to data to conclusions in an independent manner


Benefits

  • Health, dental and vision insurance
  • 401(k) program
  • Snacks provided
  • Gym on-site
  • Easy parking and access to EV charging


This is an in-person role based at our headquarters in South San Francisco, CA.



  • South San Francisco, United States Pattern Biosciences Full time

    Scientist or Senior Scientist, Functional Genomics & In Vitro ModelsPattern Biosciences South San Francisco, CA About the Company Do you want to be at the forefront of a revolution in healthcare? At Pattern, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in...


  • San Francisco, United States Site Therapeutics Full time

    Site Therapeutics aims to map—down to the nucleotide—the genetic determinants driving immune cell function in human health and disease and to use that information to develop first-in-class small molecule therapeutics for autoimmune disease. Leveraging technology developed in the Marson Lab at UCSF/Gladstone, we will conduct high-throughput functional...


  • San Francisco, United States Site Therapeutics Full time

    Site Therapeutics aims to map—down to the nucleotide—the genetic determinants driving immune cell function in human health and disease and to use that information to develop first-in-class small molecule therapeutics for autoimmune disease. Leveraging technology developed in the Marson Lab at UCSF/Gladstone, we will conduct high-throughput functional...


  • South San Francisco, United States Maze Therapeutics Full time

    The Position: Translational Genomics team is looking for an exceptional Sr. Scientist in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and mechanism...


  • South San Francisco, California, United States Alector Full time

    Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors,...


  • South San Francisco, California, United States Maze Therapeutics Full time

    The Position:Translational Genomics team is looking for an exceptional Sr. Scientist in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and mechanism...


  • South San Francisco, California, United States Maze Therapeutics Full time

    The Position:Translational Genomics team is looking for an exceptional Sr. Scientist in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and mechanism...

  • Scientist, Metabolism

    1 month ago


    South San Francisco, United States NewLimit Full time

    Company info NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...


  • South San Francisco, United States Maze Therapeutics Full time

    The Position: Translational Genomics team is looking for an exceptional Sr. Scientist I in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and...

  • Scientist, Metabolism

    1 month ago


    South San Francisco, United States NewLimit Full time

    Company infoNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...


  • South San Francisco, California, United States Maze Therapeutics Full time

    The Position:Translational Genomics team is looking for an exceptional Sr. Scientist I in statistical genetics. Maze utilizes human genetics at all stages of drug development. You will design, lead and/or execute robust genetic association studies with the goal of identifying potential drug targets. You will also contribute to target validations and...


  • San Francisco, United States General Proximity Full time

    tl;drGeneral Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.We are seeking a first-rate Genome...


  • San Francisco, United States General Proximity Full time

    tl;drGeneral Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.We are seeking a first-rate Genome...


  • South San Francisco, United States NewLimit Full time

    Company info NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning...


  • San Francisco, United States R&D Partners Full time

    R&D Partners is seeking to hire a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Contractor) in San Franciscon, CA. Your main responsibilities as a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Con Scientist, Principal, Clinical Research, Spectrometry, Chemistry, Staffing


  • South San Francisco, United States EPM Scientific Full time

    EPM Scientific are looking for a Research Scientist/Senior Research Scientist, Biophysics to come on board for one of our biggest clients in the South Francisco, CA area!Scope:1 year contract (potential extension based on performance)40 hours per weekHands on (on-site) in laboratory1 day a week WFHPosition Summary:We are seeking a talented and highly...

  • Principal Scientist

    1 month ago


    South San Francisco, United States Life Science People Full time

    Job Title: Senior Scientist/ Principal ScientistLocation: South San Francisco, CA Company Overview:Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing unmet medical needs, backed by substantial financial support, my client is poised to...

  • Principal Scientist

    1 month ago


    South San Francisco, United States Life Science People Full time

    Job Title: Senior Scientist/ Principal ScientistLocation: South San Francisco, CA Company Overview:Join a pioneering global biotech company at the forefront of cellular therapies, focusing on advanced dual-targeting CAR-T products. With a strong commitment to addressing unmet medical needs, backed by substantial financial support, my client is poised to...

  • Associate Scientist

    3 weeks ago


    San Francisco, United States Amgen Full time

    The Associate Scientist at Amgen conducts a variety of routine laboratory tasks and procedures. They assist with data collection and basic analysis under the supervision of more senior scientists. Key Responsibilities: - Design and perform _in vitro_ studies to assess the biology of novel targets and evaluate mechanisms of action of therapeutic...


  • San Francisco, United States Site Therapeutics Full time

    Site Therapeutics aims to map—down to the nucleotide—the genetic determinants driving immune cell function in human health and disease and to use that information to develop first-in-class small molecule therapeutics for autoimmune disease. Leveraging technology developed in the Marson Lab at UCSF/Gladstone, we will conduct high-throughput functional...